Development and characterization of an anthropomorphic breast software phantom based upon region-growing algorithm

Purpose: We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities.Methods: The anthropomorphic software breast phantom simu...

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Published in:Medical physics (Lancaster) Vol. 38; no. 6; pp. 3165 - 3176
Main Authors: Bakic, Predrag R., Zhang, Cuiping, Maidment, Andrew D. A.
Format: Journal Article
Language:English
Published: United States American Association of Physicists in Medicine 01-06-2011
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Abstract Purpose: We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities.Methods: The anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper’s ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically.Results: When simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom.Conclusions: A new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom.
AbstractList We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities. The anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper's ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically. When simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom. A new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom.
Purpose : We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities. Methods : The anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper's ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically. Results : When simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom. Conclusions : A new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom.
Purpose: We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities.Methods: The anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper’s ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically.Results: When simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom.Conclusions: A new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom.
PURPOSEWe present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities. METHODSThe anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper's ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically. RESULTSWhen simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom. CONCLUSIONSA new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom.
Author Zhang, Cuiping
Maidment, Andrew D. A.
Bakic, Predrag R.
Author_xml – sequence: 1
  givenname: Predrag R.
  surname: Bakic
  fullname: Bakic, Predrag R.
  email: predrag.bakic@uphs.upenn.edu
  organization: Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
– sequence: 2
  givenname: Cuiping
  surname: Zhang
  fullname: Zhang, Cuiping
  organization: Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
– sequence: 3
  givenname: Andrew D. A.
  surname: Maidment
  fullname: Maidment, Andrew D. A.
  organization: Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21815391$$D View this record in MEDLINE/PubMed
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Notes Author to whom correspondence should be addressed: Electronic mail
Tel.: (215) 746 8758; Fax: (215) 746 8764.
predrag.bakic@uphs.upenn.edu
Employed at CMART Systems, Inc.
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Snippet Purpose: We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast...
Purpose : We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast...
We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast...
PURPOSEWe present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast...
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wiley
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StartPage 3165
SubjectTerms Adipocytes - cytology
Algorithms
Anatomy
anthropometry
biological organs
Breast - anatomy & histology
Breast - cytology
Computer software
Computer‐aided diagnosis
Connective Tissue
diagnostic radiography
Humans
Image analysis
image reconstruction
Mammography
medical image processing
Medical image reconstruction
Medical imaging
Medical X‐ray imaging
modeling
phantoms
Phantoms, Imaging
Radiation Imaging Physics
Radiographic Image Enhancement
Radiography
Reconstruction
simulation of breast image acquisition
skin
Software
Ultrasonography
validation
visualization
X‐ray imaging
Title Development and characterization of an anthropomorphic breast software phantom based upon region-growing algorithm
URI http://dx.doi.org/10.1118/1.3590357
https://onlinelibrary.wiley.com/doi/abs/10.1118%2F1.3590357
https://www.ncbi.nlm.nih.gov/pubmed/21815391
https://search.proquest.com/docview/881470918
https://pubmed.ncbi.nlm.nih.gov/PMC3125083
Volume 38
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