Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects

This study examined the pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an investigational inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, in 50 healthy subjects by means of a randomized, double-blind parallel-group design. Volunteers received rising single an...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 60; no. 6; p. 687
Main Authors:	Cilla, Jr, D D, Whitfield, L R, Gibson, D M, Sedman, A J, Posvar, E L
Format:	Journal Article
Language:	English
Published:	United States 01-12-1996
Subjects:	Acyl Coenzyme A - antagonists & inhibitors Adult Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - adverse effects Anticholesteremic Agents - pharmacokinetics Anticholesteremic Agents - pharmacology Area Under Curve Atorvastatin Calcium Cholesterol - blood Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Female Half-Life Heptanoic Acids - administration & dosage Heptanoic Acids - adverse effects Heptanoic Acids - pharmacokinetics Heptanoic Acids - pharmacology Humans Least-Squares Analysis Linear Models Male Middle Aged Pyrroles - administration & dosage Pyrroles - adverse effects Pyrroles - pharmacokinetics Pyrroles - pharmacology Reference Values
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