Participation of eosinophils in the toxic oil syndrome

• Published in: Clinical and experimental immunology Vol. 82; no. 2; pp. 313 - 317
• Main Authors: TEN, R. M., KEPHART, G. M., POSADA, M., ABAITUA, I., SOLDEVILLA, L., KILBOURNE, E. M., DUNNETTE, S. L., GLEICH, G. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-11-1990; Blackwell
• Subjects: Biological and medical sciences; Blood Proteins - metabolism; Brassica; Cell Degranulation; eosinophil granule major basic protein; Eosinophil Granule Proteins; eosinophils; Eosinophils - pathology; Eosinophils - physiology; Fatty Acids, Monounsaturated; Fluorescent Antibody Technique; Food toxicology; Humans; Lung - metabolism; Lung - pathology; Medical sciences; Plant Oils - poisoning; Radioimmunoassay; Rapeseed Oil; Ribonucleases; Syndrome; toxic oil syndrome; Toxicology; Spain; Human; Europe; Edible oil; Eosinophil; Spain; Basic protein; Radioimmunoassay; Degranulation; Serum; Infiltration; Ratio; Immunofluorescence; Localization
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/j.1365-2249.1990.tb05445.x

SUMMARY
The participation of eosinophils in the Spanish toxic oil syndrome (TOS) was investigated. Eosinophil infiltration and degranulation in tissues from 52 patients with the TOS were examined by immunofluorescence staining for the eosinophil granule major basic protein (MBP). Serum MBP levels were determined in sera from 323 patients. Eosinophil infiltration and degranulation were found in several tissues, especially during the acute phase of the TOS, and serum MBP was significantly elevated during all phases of the disease, suggesting that eosinophils play a role in the pathogenesis of the TOS.