Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post auto-SCT and its correlation with survival outcome

• Published in: Bone marrow transplantation (Basingstoke) Vol. 44; no. 3; pp. 175 - 183
• Main Authors: Babatunde, A S, Tan, D C L, Heng, K K, Lee, J J, Loh, Y S M, Hwang, W Y K, Koh, M B C, Goh, Y T, Linn, Y C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-08-2009; Nature Publishing Group
• Subjects: Adolescent; Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Autografts; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Care and treatment; Cell Biology; Cell proliferation; Cytopenia; Development and progression; Engraftment; Female; Graft Rejection; Graft Survival; Hematologic and hematopoietic diseases; Hematology; Hematopoiesis; Hematopoietic stem cell disorders; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Internal Medicine; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocytes (neutrophilic); Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; original-article; Patient outcomes; Physiological aspects; Public Health; Retrospective Studies; Spontaneous recovery; Stem cell transplantation; Stem Cells; Survival; Thrombocytopenia; Thrombocytopenia - blood; Thrombocytopenia - etiology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation Conditioning; Transplants; Transplants & implants; Treatment Outcome; Young Adult; secondary cytopenia; secondary platelet decline; acute myeloid leukemia; engraftment kinetics; autologous hemopoietic stem cell transplant; Human; Acute myelogenous leukemia; Prognosis; Hematology; Malignant hemopathy; Hemopathy; Survival; Cytopenia; Autograft; Platelet; Treatment; Engraftment; Graft; Kinetics; Cancer
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/bmt.2009.1

We performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome. Following autologous transplant and engraftment, 30 patients (35.7%) had a transient secondary decline in their plt counts, which was not associated with graft rejection, relapse or infection. The median time to onset of thrombocytopenia was 59 days post transplant, with spontaneous recovery after a median period of 41 days. A secondary decline in ANC also occurred in eight patients. Patients with secondary plt decline had a significantly earlier primary plt engraftment (median 15 days) and a trend towards earlier neutrophil engraftment compared with patients who maintained steady plt counts (median 21 days). There was a trend towards a lower incidence of secondary plt decline in patients who received BM stem cells compared with those who received PBSC. No cause was evident for the occurrence of a secondary cytopenia, and it did not adversely affect survival. We conclude that secondary cytopenia is a common and harmless occurrence after autologous transplant especially from PBSC graft.