Genome-wide mapping of global-to-local genetic effects on human facial shape

Genome-wide association scans of complex multipartite traits like the human face typically use preselected phenotypic measures. Here we report a data-driven approach to phenotyping facial shape at multiple levels of organization, allowing for an open-ended description of facial variation while prese...

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Bibliographic Details
Published in:	Nature genetics Vol. 50; no. 3; pp. 414 - 423
Main Authors:	Claes, Peter, Roosenboom, Jasmien, White, Julie D., Swigut, Tomek, Sero, Dzemila, Li, Jiarui, Lee, Myoung Keun, Zaidi, Arslan, Mattern, Brooke C., Liebowitz, Corey, Pearson, Laurel, González, Tomás, Leslie, Elizabeth J., Carlson, Jenna C., Orlova, Ekaterina, Suetens, Paul, Vandermeulen, Dirk, Feingold, Eleanor, Marazita, Mary L., Shaffer, John R., Wysocka, Joanna, Shriver, Mark D., Weinberg, Seth M.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-03-2018 Nature Publishing Group
Subjects:	45/43 631/208 631/208/205 631/208/457 Adult Age Agriculture Animal Genetics and Genomics Binding sites Biomedical and Life Sciences Biomedicine Cancer Research Chromatin Chromosome Mapping Cohort Studies Face - anatomy & histology Gene Function Gene loci Gene mapping Genealogy Genetic Association Studies Genetic effects Genetics Genome-Wide Association Study Genomes Genotype Genotype & phenotype Human Genetics Humans Mapping Maxillofacial Development - genetics Multifactorial Inheritance - genetics Neural crest Phenotype Phenotyping Polymorphism, Single Nucleotide Quantitative Trait Loci Shape effects Studies United States White People - genetics Young Adult United States United States > US
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