Synchronous Breast and Cervical Carcinoma: A Genetic Point of View

• Published in: Biomedicines Vol. 11; no. 2; p. 525
• Main Authors: Yahya, Maya Mazuwin, Ismail, Mohd Pazudin, Ramanathan, Shogeta, Kadir, Muhammad Nashriq, Azhar, Azzahra, Ibrahim, Noorul Balqis Che, Wee, Chee Lee, Mohd Amin, Zahiah, Tham, Seng Kong, Mat-Sharani, Shuhaila, Yaacob, Nik Soriani
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-02-2023; MDPI
• Subjects: Anesthesia; Biopsy; Breast cancer; Breast carcinoma; Cancer; Cancer therapies; Case Report; Cervical cancer; Cervical carcinoma; Cervix; Chemoradiotherapy; Chemotherapy; concurrent chemoradiotherapy; Development and progression; Disease; Females; Gene expression; gene expression profiling; Genetic aspects; Invasiveness; Lymph nodes; Lymphatic system; Mastectomy; Medical prognosis; Medical research; Medicine, Experimental; Metastases; Metastasis; metastatic breast cancer; Neuroimaging; Pathology; Patients; Radiation therapy; Squamous cell carcinoma; Vagina; Womens health; Malaysia; United States > US; gene expression profiling; concurrent chemoradiotherapy; cervical cancer; metastatic breast cancer
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11020525

Breast carcinoma is the most common cancer of women in Malaysia. The most common sites of metastasis are the lung, liver, bone and brain. A 45-year-old lady was diagnosed with left invasive breast carcinoma stage IV (T4cN1M1) with axillary lymph nodes and lung metastasis. She was noted to have a cervical mass through imaging, and biopsy showed CIN III. Post chemotherapy, the patient underwent left simple mastectomy with examination under anaesthesia of the cervix, cystoscopy and staging. The cervical histopathological examination (HPE) showed squamous cell carcinoma, and clinical staging was 2A. The breast tissue HPE showed invasive carcinoma with triple receptors positivity. The patient was given tamoxifen and put on concurrent chemoradiotherapy (CCRT) for the cervical cancer. The management of each pathology of this patient involved a multi-disciplinary team that included surgeons, oncologists, gynaecologists, pathologists and radiologists. Due to the complexity of the case with two concurrent cancers, the gene expression profiles may help predict the patient's clinical outcome.