Blood–brain and blood–cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice

Targeting toxicity associated with β-amyloid (Aβ) misfolding and aggregation is a promising therapeutic strategy for preventing or managing Alzheimer's disease. The BRICHOS domains from human prosurfactant protein C (proSP-C) and integral membrane protein 2B (Bri2) efficiently reduce neurotoxic...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 294; no. 8; pp. 2606 - 5220
Main Authors:	Tambaro, Simone, Galan-Acosta, Lorena, Leppert, Axel, Chen, Gefei, Biverstål, Henrik, Presto, Jenny, Nilsson, Per, Johansson, Jan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 22-02-2019 American Society for Biochemistry and Molecular Biology
Subjects:	Adaptor Proteins, Signal Transducing Amyloid beta-Peptides - metabolism Animals Blood-Brain Barrier - metabolism Brain - metabolism Cell Membrane Permeability Intercellular Signaling Peptides and Proteins Male Medicin och hälsovetenskap Membrane Proteins - administration & dosage Membrane Proteins - blood Membrane Proteins - cerebrospinal fluid Mice Mice, Inbred C57BL Neurobiology neurodegenerative disease neuroscience Peptides - administration & dosage Peptides - blood Peptides - cerebrospinal fluid protein aggregation protein assembly protein domain Protein Domains protein misfolding Pulmonary Surfactant-Associated Protein C protein domain neurodegenerative disease protein assembly protein misfolding neuroscience protein aggregation
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