LGA: a method for finding 3D similarities in protein structures

We present the LGA (Local-Global Alignment) method, designed to facilitate the comparison of protein structures or fragments of protein structures in sequence dependent and sequence independent modes. The LGA structure alignment program is available as an online service at http://PredictionCenter.ll...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 31; no. 13; pp. 3370 - 3374
Main Author:	Zemla, Adam
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-07-2003 Oxford Publishing Limited (England)
Subjects:	Algorithms Computer Graphics Databases, Protein Internet Models, Molecular Molecular Structure Nuclear Magnetic Resonance, Biomolecular Proteins - chemistry Sequence Alignment Software Structural Homology, Protein
Online Access:	Get full text
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Summary:	We present the LGA (Local-Global Alignment) method, designed to facilitate the comparison of protein structures or fragments of protein structures in sequence dependent and sequence independent modes. The LGA structure alignment program is available as an online service at http://PredictionCenter.llnl.gov/local/lga. Data generated by LGA can be successfully used in a scoring function to rank the level of similarity between two structures and to allow structure classification when many proteins are being analyzed. LGA also allows the clustering of similar fragments of protein structures.
Bibliography:	ark:/67375/HXZ-3QQ6N6ZP-V Received February 16, 2003; Revised and Accepted April 4, 2003 istex:4C750FDCAA9F8E32D1330B1019289536D2E3A85E local:gkg571 Tel: +1 925 423 5571; Fax: +1 925 422 2133; Email: adamz@llnl.gov ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0305-1048 1362-4962 1362-4962
DOI:	10.1093/nar/gkg571