A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis

In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the C. trachomatis surface, suggesting that its target is bacte...

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Bibliographic Details
Published in:mBio Vol. 6; no. 1; pp. e02304 - e02314
Main Authors: Engström, Patrik, Krishnan, K Syam, Ngyuen, Bidong D, Chorell, Erik, Normark, Johan, Silver, Jim, Bastidas, Robert J, Welch, Matthew D, Hultgren, Scott J, Wolf-Watz, Hans, Valdivia, Raphael H, Almqvist, Fredrik, Bergström, Sven
Format: Journal Article
Language:English
Published: United States American Society of Microbiology 30-12-2014
American Society for Microbiology
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