Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

• Published in: International journal of pharmaceutics Vol. 278; no. 1; pp. 71 - 77
• Main Authors: Souto, E.B, Wissing, S.A, Barbosa, C.M, Müller, R.H
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 18-06-2004; Elsevier
• Subjects: Administration, Topical; Biological and medical sciences; Chemistry, Pharmaceutical; Clotrimazole; Clotrimazole - administration & dosage; Clotrimazole - pharmacokinetics; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Drug Carriers - administration & dosage; Drug Carriers - pharmacokinetics; Franz diffusion cells; General pharmacology; Liposomes; Medical sciences; Nanostructured lipid carriers; Nanotechnology - methods; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Solid lipid nanoparticles; Nanostructured lipid carriers; Franz diffusion cells; Solid lipid nanoparticles; Clotrimazole; Imidazole derivatives; Antifungal agent; Nanoparticle; Formulation; Lipids; Diffusion; Cell; Topical administration
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2004.02.032

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40
°C. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10
h.