Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development

Experimental and clinical evidence points to a critical role of progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland tumorigenesis. However, the molecular mechanisms of progesterone action in breast cancer still remain elusive. On the other hand, micro RNAs (miRNAs) a...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 14; no. 3; p. R77
Main Authors:	Rivas, Martin A, Venturutti, Leandro, Huang, Yi-Wen, Schillaci, Roxana, Huang, Tim Hui-Ming, Elizalde, Patricia V
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 14-05-2012 BioMed Central
Subjects:	3' Untranslated regions 3' Untranslated Regions - genetics Acids Analysis Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism c-Myc protein Cell cycle Cell Line, Tumor Cell Proliferation Cyclin E Cyclin E - genetics Cyclin E - metabolism Development and progression Down-Regulation ErbB protein Female Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genome-Wide Association Study Genomics heregulin Humans Leukemia Mammary gland Mice Mice, Inbred BALB C MicroRNA MicroRNAs - metabolism miRNA Molecular modelling Oncogene Proteins - genetics Oncogene Proteins - metabolism Physiological aspects Progestational hormones Progesterone Progesterone receptors progestin Progestins - metabolism Proteins - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Reporter gene RNA Interference RNA, Small Interfering Signal Transduction Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription factors Tumor cell lines Tumor cells Tumor suppressor genes Tumorigenesis Up-Regulation Western blotting
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