On the behavior of HPMC/Theophylline matrices for controlled drug delivery

• Published in: Journal of pharmaceutical sciences Vol. 98; no. 11; p. 4100
• Main Authors: Barba, Anna Angela, d'Amore, Matteo, Cascone, Sara, Chirico, Serafina, Lamberti, Gaetano, Titomanlio, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States 01-11-2009
• Subjects: Diffusion; Drug Carriers; Drug Delivery Systems; Hydrogel, Polyethylene Glycol Dimethacrylate; Hypromellose Derivatives; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Models, Chemical; Powders; Solubility; Temperature; Theophylline - chemistry; Time Factors; Water - chemistry
• ISSN: 1520-6017
• DOI: 10.1002/jps.21701

Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon.