Effect of tramadol gargle on postoperative sore throat: A double blinded randomized placebo controlled study

• Published in: Egyptian journal of anaesthesia Vol. 30; no. 3; pp. 235 - 239
• Main Authors: Rashwan, Samaa, Abdelmawgoud, Ashraf, Badawy, Ahmed A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-07-2014; Taylor & Francis; Taylor & Francis Group
• Subjects: Postoperative sore throat; Tramadol; Tramadol; Postoperative sore throat
• ISSN: 1110-1849; 1687-1804; 1110-1849
• DOI: 10.1016/j.egja.2014.01.010

Postoperative sore throat is an undesirable complaint after general anesthesia with laryngeal mask airway. Tramadol is a synthetic codeine analogue with NMDA receptor antagonist and local anesthetic effects. We compared tramadol gargle to placebo given 5min before surgery on attenuating postoperative sore throat for 24 postoperative hours.
In a prospective randomized double blind study, fifty patients of ASA I and II, undergoing elective moderate urological surgery under general anesthesia using laryngeal mask airway were allocated into two groups (25 patients each); all patients were asked to gargle for 1min with 30ml apple juice containing tramadol 2mg/kg in group (T), and nothing in group (P) 5min before surgery. The incidence and the severity of postoperative sore throat were graded at 2, 6, 12, and 24h after surgery using a four-point scale.
Incidence and severity of postoperative sore throat were significantly less in tramadol treated group compared to placebo group at 2, 6, 12, and 24h (p<0.05).
Preoperative gargling with tramadol reduced the incidence and severity of POST compared to placebo group in patients undergoing elective moderate urological surgery, during general anesthesia with laryngeal mask airway for up to 24h postoperatively.