Phenotypic and functional evaluation of CD3+CD4−CD8− T cells in human CD8 immunodeficiency

Human CD8 immunodeficiency is characterized by undetectable CD8(+) lymphocytes and an increased population of CD4(-)CD8(-) (double negative) T lymphocytes. We hypothesized that the double negative subset corresponds to the cellular population that should express CD8 and is committed to the cytotoxic...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 96; no. 8; pp. 1195 - 1203
Main Authors:	BERNARDO, Iván, MANCEBO, Esther, GONZALEZ-SANTESTEBAN, Cecilia, PAZ-ARTAL, Estela, AGUILO, Ignacio, ANEL, Alberto, ALLENDE, Luis M, GUERRA-VALES, Juan M, RUIZ-CONTRERAS, Jesus, SERRANO, Antonio, TALAYERO, Paloma, DE LA CALLE, Oscar
Format:	Journal Article
Language:	English
Published:	Pavia Ferrata Storti Foundation 01-08-2011
Subjects:	Adolescent Adult Biological and medical sciences CD8 Antigens - genetics CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - immunology Cytoplasm - metabolism Cytotoxicity, Immunologic Female Flow Cytometry Gene Expression Regulation - immunology Hematologic and hematopoietic diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Immunophenotyping Medical sciences Mutation - genetics Original Phenotype Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Human Cell proliferation Immunopathology HLA-System Hematology Major histocompatibility system cytotoxic T lymphocyte proliferation Immune deficiency CD8 immunodeficiency Phenotype T-Lymphocyte double negative T lympho cytes Suppressive cell Cytotoxic T lymphocyte MHC class-I Class I histocompatibility antigen CD8 T lymphocyte
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