High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy

• Published in: NeuroImage clinical Vol. 12; no. C; pp. 928 - 939
• Main Authors: Zweiphenning, W J E M, van 't Klooster, M A, van Diessen, E, van Klink, N E C, Huiskamp, G J M, Gebbink, T A, Leijten, F S S, Gosselaar, P H, Otte, W M, Stam, C J, Braun, K P J, Zijlmans, G J M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01-01-2016
• Subjects: Adolescent; Adult; Brain Waves - physiology; Child; Child, Preschool; Electrocorticography - methods; Epilepsy; Epilepsy - physiopathology; Epilepsy - surgery; Epileptogenic zone; Female; Functional network analysis; Gamma Rhythm - physiology; High Frequency Oscillations; Humans; Male; Middle Aged; Nerve Net - physiopathology; Regular; Young Adult; HFO, high frequency oscillation, > 80 Hz; Epilepsy; EC, eigenvector centrality; TLE, temporal lobe epilepsy; Epilepsy surgery; FR, fast ripple, 250–500 Hz; SOZ, seizure onset zone; EEG, electroencephalography; PLI, phase lag index; High Frequency Oscillations; Functional network analysis; IPSP, inhibitory postsynaptic potential; Epileptogenic zone; (io)ECoG, (intra-operative) electrocorticography
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2016.09.014

High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and 'baseline' functional connectivity within EEG networks, especially in the high frequency bands.
We marked FRs, ripples (80-250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy. We assessed 'baseline' functional connectivity in epochs free of epileptiform events within these recordings, using the phase lag index. We computed the Eigenvector Centrality (EC) per channel in the FR and gamma band network. We compared EC between channels that did or did not show events at other moments in time.
FR-band EC was higher in channels with than without spikes. Gamma-band EC was lower in channels with ripples and FRs.
We confirmed previous findings of functional isolation in the gamma-band and found a first proof of functional integration in the FR-band network of channels covering presumed epileptogenic tissue.
'Baseline' high-frequency network parameters might help intra-operative recognition of epileptogenic tissue without the need for waiting for events. These findings can increase our understanding of the 'architecture' of epileptogenic networks and help unravel the pathophysiology of HFOs.