Characteristics and predictive factors of visual function improvements after monocular perceptual learning in amblyopia
Monocular perceptual learning has shown promising performance in restoring visual function in amblyopes beyond the critical period in the laboratory. However, the treatment outcome is variable and indeterminate in actual clinical and neuroscientific practice. We aimed to explore the efficacy of mono...
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| Published in: | Heliyon Vol. 9; no. 6; p. e17281 |
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01-06-2023
Elsevier |
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| Abstract | Monocular perceptual learning has shown promising performance in restoring visual function in amblyopes beyond the critical period in the laboratory. However, the treatment outcome is variable and indeterminate in actual clinical and neuroscientific practice. We aimed to explore the efficacy of monocular perceptual learning in the clinical setting. By combining continuous monitoring of perceptual learning and clinical measurements, we evaluated the efficacy and characteristics of visual acuity and contrast sensitivity function improvement and further explored the individualized effect after perceptual learning. Amblyopes (average age:17 ± 7 years old) were trained in a monocular two-alternative forced choice identification task at the 50% contrast threshold of the amblyopic eye for 10–15 days. We found that monocular perceptual learning improves both visual acuity and contrast sensitivity function in amblyopia. The broader activation of spatial contrast sensitivity, with a significant improvement in lower spatial frequencies, contributed to improving visual acuity. Visual acuity changes in the early stage can predict the endpoint treatment outcomes. Our results confirm the efficacy of monocular perceptual learning and suggest potential predictors of training outcomes to assist in the future management of clinical intervention and vision neuroscience research in amblyopia beyond the critical period of visual plasticity. |
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| AbstractList | Monocular perceptual learning has shown promising performance in restoring visual function in amblyopes beyond the critical period in the laboratory. However, the treatment outcome is variable and indeterminate in actual clinical and neuroscientific practice. We aimed to explore the efficacy of monocular perceptual learning in the clinical setting. By combining continuous monitoring of perceptual learning and clinical measurements, we evaluated the efficacy and characteristics of visual acuity and contrast sensitivity function improvement and further explored the individualized effect after perceptual learning. Amblyopes (average age:17 ± 7 years old) were trained in a monocular two-alternative forced choice identification task at the 50% contrast threshold of the amblyopic eye for 10–15 days. We found that monocular perceptual learning improves both visual acuity and contrast sensitivity function in amblyopia. The broader activation of spatial contrast sensitivity, with a significant improvement in lower spatial frequencies, contributed to improving visual acuity. Visual acuity changes in the early stage can predict the endpoint treatment outcomes. Our results confirm the efficacy of monocular perceptual learning and suggest potential predictors of training outcomes to assist in the future management of clinical intervention and vision neuroscience research in amblyopia beyond the critical period of visual plasticity. |
| ArticleNumber | e17281 |
| Author | Liu, Jing Zhou, Yusong Jiang, Rengang Yuan, Junpeng Ye, Qingqing Wen, Yun Yao, Ying He, Yunsi Jia, Yu Zhuang, Yijing Chen, Xiaolan Feng, Lei Xu, Zixuan Li, Jinrong |
| Author_xml | – sequence: 1 givenname: Yunsi surname: He fullname: He, Yunsi – sequence: 2 givenname: Lei surname: Feng fullname: Feng, Lei – sequence: 3 givenname: Yusong surname: Zhou fullname: Zhou, Yusong – sequence: 4 givenname: Yijing surname: Zhuang fullname: Zhuang, Yijing – sequence: 5 givenname: Zixuan surname: Xu fullname: Xu, Zixuan – sequence: 6 givenname: Ying surname: Yao fullname: Yao, Ying – sequence: 7 givenname: Xiaolan surname: Chen fullname: Chen, Xiaolan – sequence: 8 givenname: Rengang surname: Jiang fullname: Jiang, Rengang – sequence: 9 givenname: Junpeng surname: Yuan fullname: Yuan, Junpeng – sequence: 10 givenname: Qingqing surname: Ye fullname: Ye, Qingqing – sequence: 11 givenname: Yun orcidid: 0000-0002-3703-0049 surname: Wen fullname: Wen, Yun – sequence: 12 givenname: Yu surname: Jia fullname: Jia, Yu – sequence: 13 givenname: Jing surname: Liu fullname: Liu, Jing email: jingliu030@qq.com – sequence: 14 givenname: Jinrong orcidid: 0000-0002-5732-7579 surname: Li fullname: Li, Jinrong email: lijingr3@mail.sysu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37416659$$D View this record in MEDLINE/PubMed |
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| Keywords | Perceptual learning Visual plasticity Predict outcomes Contrast sensitivity function Amblyopia |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2023 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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