Controlling the mitochondrial antisense - role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance

Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT...

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Bibliographic Details
Published in:	Molecular & cellular oncology Vol. 5; no. 6; p. e1516452
Main Authors:	Pietras, Zbigniew, Wojcik, Magdalena A., Borowski, Lukasz S., Szewczyk, Maciej, Kulinski, Tomasz M., Cysewski, Dominik, Stepien, Piotr P., Dziembowski, Andrzej, Szczesny, Roman J.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02-11-2018 Taylor & Francis Group
Subjects:	Author’s Views G-quadraplexes GRSF1 mitochondrial RNA PNPase RNA surveillance SUV3 RNA surveillance mitochondrial RNA G-quadraplexes PNPase SUV3 GRSF1 G4
Online Access:	Get full text
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Summary:	Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT1 (also known as PNPase), together with G4-melting protein GRSF1, is a key player in restricting antisense mtRNAs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/kmco.
ISSN:	2372-3556 2372-3556
DOI:	10.1080/23723556.2018.1516452