Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies

• Published in: Human vaccines & immunotherapeutics Vol. 15; no. 3; pp. 594 - 602
• Main Authors: Burt, Richard, Warcel, Dana, Fielding, Adele K.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 04-03-2019; Taylor & Francis Group
• Subjects: acute lymphoblastic Leukaemia; Animals; Antibodies, Bispecific - immunology; Antibodies, Bispecific - therapeutic use; Antigens, CD19 - immunology; Antineoplastic Agents - immunology; Antineoplastic Agents - therapeutic use; B-cell non hodgkin Lymphoma; B-Lymphocytes - immunology; blinatumomab; Clinical Trials as Topic; Disease Models, Animal; Drug Development; Humans; immunotherapeutics; Immunotherapy; Lymphoma, B-Cell - immunology; Lymphoma, B-Cell - therapy; Lymphoma, Non-Hodgkin - immunology; Lymphoma, Non-Hodgkin - therapy; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Product Review; T-Lymphocytes - immunology; acute lymphoblastic Leukaemia; blinatumomab; B-cell non hodgkin Lymphoma; immunotherapeutics
• ISSN: 2164-5515; 2164-554X
• DOI: 10.1080/21645515.2018.1540828

Blinatumomab (Blincyto, Amgen), a bi-specific antibody, is a first-in-class, targeted immunotherapy agent for treatment of B-cell malignancies with a novel mechanism of action which involves in-vivo engagement of the patient's T cells with CD19-expressing tumour cells. Clinical trials have demonstrated its efficacy in relapsed B-cell Acute Lymphoblastic Leukaemia (B-ALL) and B-cell Non-Hodgkin's Lymphoma including in patients who are refractory to chemotherapy. This review summarises the development and design of Blinatumomab, the outcome of clinical studies demonstrating its efficacy and how to manage the administration, practically, including relevant toxicities. We compare and contrast it to other emerging agents for treatment of B-cell malignancies.