Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2-1.4. However, the underlying action mechanis...

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Bibliographic Details
Published in:	Channels (Austin, Tex.) Vol. 16; no. 1; pp. 72 - 83
Main Authors:	Dehong, Xu, Wenmei, Wu, Siqin, Hong, Peng, Zeng, Xianchun, Wang, Xiongzhi, Zeng
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 31-12-2022 Taylor & Francis Group
Subjects:	Animals electrophysiological assays HEK293 Cells Humans JZTX-V kv4.3 molecular determinants mutants Neurons Peptides - pharmacology Research Paper Spider Venoms - pharmacology Spiders molecular determinants electrophysiological assays kv4.3 mutants JZTX-V
Online Access:	Get full text
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