An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

Microvillus inclusion disease (MVID) is a rare intestinal enteropathy with an onset within a few days to months after birth, resulting in persistent watery diarrhea. Mutations in the myosin Vb gene (MYO5B) have been identified in the majority of MVID patients. However, the exact pathophysiology of M...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 40; pp. 12408 - 12413
Main Authors:	Schneeberger, Kerstin, Vogel, Georg F., Teunissen, Hans, van Ommen, Domenique D., Begthel, Harry, Bouazzaoui, Layla El, van Vugt, Anke H. M., Beekman, Jeffrey M., Klumperman, Judith, Müller, Thomas, Janecke, Andreas, Gerner, Patrick, Huber, Lukas A., Hess, Michael W., Clevers, Hans, van Es, Johan H., Nieuwenhuis, Edward E. S., Middendorp, Sabine
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 06-10-2015 National Acad Sciences
Subjects:	Animals Biological Sciences Diarrhea Disease Models, Animal Electron microscopy Enterocytes - metabolism Enterocytes - pathology Enterocytes - ultrastructure Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - ultrastructure Female Genotype & phenotype Humans Immunohistochemistry Intestines - metabolism Intestines - pathology Intestines - ultrastructure Malabsorption Syndromes - chemically induced Malabsorption Syndromes - metabolism Male Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Mice, Transgenic Microscopy, Confocal Microscopy, Electron, Transmission Microvilli - metabolism Microvilli - pathology Microvilli - ultrastructure Mucolipidoses - chemically induced Mucolipidoses - metabolism Mutation Myosin Type V - genetics Myosin Type V - metabolism Organ Culture Techniques Physiology Protein Transport - genetics Protein Transport - physiology Rodents Tamoxifen epithelila polarity intestinal enteropathy microvillus inclusion disease myosin Vb mouse model
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!