Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats

• Published in: Journal of pharmacological sciences Vol. 130; no. 2; pp. 136 - 138
• Main Authors: Okuma, Chihiro, Ohta, Takeshi, Ito, Makoto, Tadaki, Hironobu, Oda, Tomohiro, Kume, Shinichi, Nishiu, Jun, Kakutani, Makoto
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 01-02-2016; Elsevier
• Subjects: Animals; Depression, Chemical; Diarrhea; Diarrhea - etiology; Eating - drug effects; Fatty Acids - administration & dosage; Fatty Acids - pharmacology; Fatty Acids - physiology; Food intake; Jejunum; Male; Monoacylglycerol; Monoglycerides - administration & dosage; Monoglycerides - pharmacology; Monoglycerides - physiology; Rats, Sprague-Dawley; Satiation - drug effects; Stimulation, Chemical; Diarrhea; Food intake; Monoacylglycerol
• ISSN: 1347-8613; 1347-8648
• DOI: 10.1016/j.jphs.2016.01.004

Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the digestive products of triglycerides, on food intake is still unclear. In the present study, the effects of 2-MG on food intake and diarrhea were evaluated and compared with long-chain fatty acid (LCFA) in rats by intrajejunal infusion.
Intrajejunal infusion of 2-MG reduced food intake. In addition, 2-MG did not induce diarrhea at the condition that it comparably reduced food intake as compared with LCFA. These results suggest that 2-MG stimulates satiety without inducing diarrhea, different from LCFA.