Application of triazoles in the structural modification of natural products

Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthe...

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Bibliographic Details
Published in:	Journal of enzyme inhibition and medicinal chemistry Vol. 36; no. 1; pp. 1115 - 1144
Main Authors:	Guo, Hong-Yan, Chen, Zheng-Ai, Shen, Qing-Kun, Quan, Zhe-Shan
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01-01-2021 Taylor & Francis Group
Subjects:	biological activity Biological Products - chemistry Biological Products - pharmacology Cell Line, Tumor Chemistry, Pharmaceutical Humans Microbial Sensitivity Tests Molecular Structure Natural products Review Structure-Activity Relationship triazole Triazoles - chemistry Natural products biological activity triazole
Online Access:	Get full text
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Summary:	Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compounds reportedly exert anticancer, anti-inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, anti-Alzheimer, and enzyme inhibitory effects. This review summarises the research progress of triazole-containing natural product derivatives involved in medicinal chemistry in the past six years. This review provides insights and perspectives that will help scientists in the fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work and should be considered co-first authors.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756366.2021.1890066