Regional Cerebral Blood Flow Using Quantitative MR Angiography

• Published in: American Journal of Neuroradiology Vol. 28; no. 8; pp. 1470 - 1473
• Main Authors: Zhao, M, Amin-Hanjani, S, Ruland, S, Curcio, A.P, Ostergren, L, Charbel, F.T
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Am Soc Neuroradiology 01-09-2007; American Society of Neuroradiology
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aging - physiology; Algorithms; Biological and medical sciences; Brain; Cardiovascular system; Carotid Artery, Common - physiology; Cerebrovascular Circulation; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Angiography; Male; Medical sciences; Middle Aged; Miscellaneous; Mood disorders; Nervous system; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reference Values; Regional Blood Flow; Retrospective Studies; Sex Factors; Regional blood flow; Nervous system diseases; Radiodiagnosis; Central nervous system; Hemodynamics; NMR angiography; Encephalon
• ISSN: 0195-6108; 1936-959X; 1432-1920
• DOI: 10.3174/ajnr.A0582

We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA).
Flow rates in the 15 major cerebral arteries were measured on retrospectively gated fast 2D phase-contrast MR angiography obtained in 83 healthy adult volunteers (age range, 24-74 years; mean, 42 years). The arterial network of the brain was partitioned into 12 different regions, in which flows were calculated from the measured flows of the 15 cerebral arteries.
The mean flows of the 15 arteries and the 12 regions were calculated. The mean total cranial flow and the mean total cerebral blood flow were 949 +/- 158 mL/min and 695 +/- 113 mL/min, respectively. The mean regional flows for the anterior and posterior circulation were 483 +/- 87 mL/min and 212 +/- 34 mL/min, respectively. The relative contributions of the flows in the 11 regions to their parent regions were obtained. The mean flows in the individual arteries and the regions with age were also calculated. The mean flows for the female group were significantly lower than those for the male group (P < .001) for the 2 common carotids and the cranial circulation and left/right extracranial circulation. However, the intracranial circulation was not different between sexes.
The 12 regions in the cerebral circulation were identified and formed into a partition tree, and the mean regional flow for each region was determined using vessel flows from qMRA.