Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings
To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment drama...
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| Published in: | Microbiology (Society for General Microbiology) Vol. 145; no. 11; pp. 3229 - 3234 |
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| Abstract | To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. |
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| AbstractList | To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo and Universidade de Franca, Av. do Café S/N, CEP 14040-903, Ribeirão Preto, São Paulo, Brazil 1 Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil 2 Instituto de Fisiologia Celular-UNAM, Mexico City, Mexico 3 Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID, USA 4 Author for correspondence: Gustavo H. Goldman. Tel: +55 16 6024280/81. Fax: +55 16 6331092/6024280. e-mail: ggoldman{at}usp.br To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA . Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 °C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress. Keywords: catalase, heat shock, stress tolerance, Aspergillus nidulans Abbreviations: ROS, reactive oxygen species |
| Author | Goldman, M.H.S Goldman, G.H Iyer, S Aguirre, J Terenzi, H.F Noventa-Jordao, M.A Couto, R.M Caplan, A |
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| Cites_doi | 10.1128/jb.179.10.3284-3292.1997 10.1111/j.1574-6968.1997.tb12639.x 10.1016/S0065-2660(08)60245-X 10.1128/MMBR.59.3.506-531.1995 10.1074/jbc.273.35.22480 10.1172/JCI108786 10.1099/13500872-140-12-3277 10.1073/pnas.83.21.8059 10.1016/0014-5793(94)01207-5 10.1128/JB.180.21.5733-5738.1998 10.1007/978-3-662-10367-8_19 10.1046/j.1365-2958.1996.403940.x 10.1099/00221287-142-4-937 10.1016/S0065-2660(08)60522-2 10.4049/jimmunol.156.10.3836 10.1128/jb.179.1.157-162.1997 10.1073/pnas.93.10.5116 10.1016/S0021-9258(18)98912-X 10.1021/ja00899a032 |
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| Keywords | Oxidative stress Trehalose Enzyme Gene expression Hydrogen Peroxides Fungi Resistance Peroxidases Catalase Aspergillus nidulans Thermal shock Mannitol Fungi Imperfecti Oxidoreductases Thallophyta |
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| References | Donnely (R6) 1994; 355 Navarro (R16) 1996; 29 Santoro (R19) 1997 Jorge (R9) 1997; 154 Scandalios (R20) 1990; 28 Navarro (R15) 1998; 180 Sweeley (R21) 1963; 85 Tauber (R22) 1977; 60 Thevelein (R23) 1996 Piper (R17) 1997 Wieser (R24) 1991; 266 Kawasaki (R11) 1997; 179 Brobst (R1) 1966; 43 Godon (R7) 1998; 273 Kafer (R10) 1977; 19 Sambrook (R18) 1989 Mager (R12) 1995; 59 Chaturvedi (R3) 1996b; 156 Moradas-Ferreira (R13) 1996; 19 Davidson (R5) 1996; 93 Jamieson (R8) 1994; 140 Morgan (R14) 1986; 83 Chaturvedi (R4) 1997; 179 Chaturvedi (R2) 1996a; 142 |
| References_xml | – volume: 179 start-page: 3284 year: 1997 ident: R11 article-title: Two divergent catalase genes are differentially regulated during Aspergillus nidulans development and oxidative stress publication-title: J Bacteriol doi: 10.1128/jb.179.10.3284-3292.1997 contributor: fullname: Kawasaki – volume: 154 start-page: 165 year: 1997 ident: R9 article-title: Trehalases and trehalose hydrolysis in fungi publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.1997.tb12639.x contributor: fullname: Jorge – start-page: 171 year: 1997 ident: R19 article-title: Oxidative stress responses in the yeast publication-title: Yeast Stress Responses contributor: fullname: Santoro – volume: 19 start-page: 33 year: 1977 ident: R10 article-title: Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations publication-title: Adv Genet doi: 10.1016/S0065-2660(08)60245-X contributor: fullname: Kafer – volume: 59 start-page: 506 year: 1995 ident: R12 article-title: 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10.1128/jb.179.1.157-162.1997 contributor: fullname: Chaturvedi – volume: 93 start-page: 5116 year: 1996 ident: R5 article-title: Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae. publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.10.5116 contributor: fullname: Davidson – volume: 266 start-page: 12406 year: 1991 ident: R24 article-title: Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae. publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)98912-X contributor: fullname: Wieser – volume: 85 start-page: 2497 year: 1963 ident: R21 article-title: Gas-liquid chromatography of trimethylsilyl derivatives of sugars and related substances publication-title: J Am Chem Soc doi: 10.1021/ja00899a032 contributor: fullname: Sweeley |
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| SubjectTerms | Action of physical and chemical agents Aspergillus nidulans Aspergillus nidulans - drug effects Aspergillus nidulans - enzymology Aspergillus nidulans - physiology Biological and medical sciences Blotting, Northern catA gene Catalase - genetics Catalase - metabolism Chromatography, Gas Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Fungal Proteins - metabolism Gene Deletion Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism hydrogen peroxide Hydrogen Peroxide - pharmacology mannitol Mannitol - metabolism Microbiology Mycology plant biochemistry plant physiology RNA, Fungal - analysis RNA, Messenger - analysis Time Factors Trehalose - metabolism |
| Title | Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings |
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