Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuronal cells, exposure to PA inhibits the autophagic f...

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Bibliographic Details
Published in:	Molecular & cellular oncology Vol. 7; no. 5; p. 1789418
Main Authors:	Hernández-Cáceres, María Paz, Cereceda, Karina, Hernández, Sergio, Li, Ying, Narro, Carla, Rivera, Patricia, Silva, Patricio, Ávalos, Yenniffer, Jara, Claudia, Burgos, Paulina, Toledo-Valenzuela, Lilian, Lagos, Pablo, Cifuentes Araneda, Flavia, Perez-Leighton, Claudio, Bertocchi, Cristina, Clegg, Deborah J., Criollo, Alfredo, Tapia-Rojas, Cheril, Burgos, Patricia V., Morselli, Eugenia
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02-09-2020 Taylor & Francis Group
Subjects:	autophagy central nervous system electron microscopy high-fat diet hypothalamic neuronal cells lysosomes obesity-associated cancers Palmitic acid Rab7 Research Paper Rab7 autophagy high-fat diet electron microscopy hypothalamic neuronal cells obesity-associated cancers lysosomes Palmitic acid central nervous system
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