DNA Sequences Similar to Those of Simian Virus 40 in Ependymomas and Choroid Plexus Tumors of Childhood

• Published in: The New England journal of medicine Vol. 326; no. 15; pp. 988 - 993
• Main Authors: Bergsagel, Daniel J, Finegold, Milton J, Butel, Janet S, Kupsky, William J, Garcea, Robert L
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 09-04-1992
• Subjects: Animal models; Antigens; Antigens, Viral, Tumor - analysis; Antigens, Viral, Tumor - genetics; Base Sequence; Biological and medical sciences; BK Virus - genetics; Brain cancer; Cancer; Child, Preschool; Children; Children & youth; Chloride; Choroid plexus; Choroid Plexus Neoplasms - genetics; Choroid Plexus Neoplasms - microbiology; Deoxyribonucleic acid; DNA; DNA probes; DNA sequencing; DNA, Neoplasm - analysis; DNA, Viral - analysis; Ependymoma - genetics; Ependymoma - microbiology; Genetic testing; Hospitals; Humans; Hybridization; Infant; JC Virus - genetics; Laboratory animals; Medical sciences; Molecular Sequence Data; Neoplasia; Neuroblastoma; Neurology; Nuclei; Nucleotide sequence; Polymerase Chain Reaction; Primers; Simian virus 40 - genetics; Sodium; Tumors; Tumors of the nervous system. Phacomatoses; Viruses; Human; Virus; Choroid plexus; DNA; Polyomavirus; Papilloma; Tumor; Papovaviridae; SV40 virus; Child; Ependymoma
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199204093261504

EPIDEMIOLOGIC studies have shown that 70 to 80 percent of adults are seropositive for the human polyomaviruses BK and JC.
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,
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BK virus, originally discovered in the urine of a renal-transplant recipient,
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is thought to be a cause of hemorrhagic cystitis and nephritis in immunosuppressed patients. JC virus, which infects oligodendrocytes, has been linked with progressive multifocal leukoencephalopathy.
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Both viruses are presumably acquired as primary infections in childhood, and they persist benignly in the immunocompetent host. The monkey polyomavirus simian virus 40 (SV40), a potent virus that induces tumors in laboratory animals, was found to be a contaminant of polio vaccines . . .