Fluconazole Prophylaxis against Fungal Colonization and Infection in Preterm Infants
Invasive fungal infections cause substantial morbidity and mortality in preterm infants. In this single-center, double-blind, placebo-controlled trial, extremely-low-birth-weight preterm infants who were given the antifungal agent fluconazole prophylactically for six weeks had significantly lower ra...
Saved in:
| Published in: | The New England journal of medicine Vol. 345; no. 23; pp. 1660 - 1666 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Boston, MA
Massachusetts Medical Society
06-12-2001
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Invasive fungal infections cause substantial morbidity and mortality in preterm infants. In this single-center, double-blind, placebo-controlled trial, extremely-low-birth-weight preterm infants who were given the antifungal agent fluconazole prophylactically for six weeks had significantly lower rates of fungal colonization and systemic fungal infection than control infants, without development of resistance to fluconazole or adverse effects on liver enzymes.
The use of fluconazole reduced the incidence of invasive fungal infection in extremely-low-birth-weight infants.
Despite aggressive antifungal treatment of invasive candida infection, systemic fungal disease is increasing in prevalence and leads to high rates of illness and death among preterm infants.
1
,
2
Candida species rapidly colonize the skin and mucous membranes of about 60 percent of critically ill neonates and can progress to invasive infection.
2
,
3
Fungal infection accounts for 9 percent of cases of late-onset sepsis in infants who weigh less than 1500 g and is associated with a mortality rate of 28 percent, as compared with 7 percent among infants in whom no infection develops.
1
Critically ill neonates are at an increased . . . |
|---|---|
| AbstractList | Invasive fungal infections cause substantial morbidity and mortality in preterm infants. In this single-center, double-blind, placebo-controlled trial, extremely-low-birth-weight preterm infants who were given the antifungal agent fluconazole prophylactically for six weeks had significantly lower rates of fungal colonization and systemic fungal infection than control infants, without development of resistance to fluconazole or adverse effects on liver enzymes.
The use of fluconazole reduced the incidence of invasive fungal infection in extremely-low-birth-weight infants.
Despite aggressive antifungal treatment of invasive candida infection, systemic fungal disease is increasing in prevalence and leads to high rates of illness and death among preterm infants.
1
,
2
Candida species rapidly colonize the skin and mucous membranes of about 60 percent of critically ill neonates and can progress to invasive infection.
2
,
3
Fungal infection accounts for 9 percent of cases of late-onset sepsis in infants who weigh less than 1500 g and is associated with a mortality rate of 28 percent, as compared with 7 percent among infants in whom no infection develops.
1
Critically ill neonates are at an increased . . . Background Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight infants. Methods We conducted a prospective, randomized, double-blind clinical trial over a 30-month period in 100 preterm infants with birth weights of less than 1000 g. The infants were randomly assigned during the first five days of life to receive either intravenous fluconazole or placebo for six weeks. We obtained weekly surveillance cultures from all patients. Results The 50 infants randomly assigned to fluconazole and the 50 control infants were similar in terms of birth weight, gestational age at birth, and base-line risk factors for fungal infection. During the six-week treatment period, fungal colonization was documented in 30 infants in the placebo group (60 percent) and 11 infants in the fluconazole group (22 percent; difference in risk, 0.38; 95 percent confidence interval, 0.18 to 0.56; P=0.002). Invasive fungal infection with positive growth of fungal isolates from the blood, urine, or cerebrospinal fluid developed in 10 infants in the placebo group (20 percent) and none of the infants in the fluconazole group (difference in risk, 0.20; 95 percent confidence interval, 0.04 to 0.36; P=0.008). The sensitivities of the fungal isolates to fluconazole did not change during the study, and no adverse effects of the fluconazole therapy were documented. Conclusions Prophylactic administration of fluconazole during the first six weeks of life is effective in preventing fungal colonization and invasive fungal infection in infants with birth weights of less than 1000 g. Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight infants. We conducted a prospective, randomized, double-blind clinical trial over a 30-month period in 100 preterm infants with birth weights of less than 1000 g. The infants were randomly assigned during the first five days of life to receive either intravenous fluconazole or placebo for six weeks. We obtained weekly surveillance cultures from all patients. The 50 infants randomly assigned to fluconazole and the 50 control infants were similar in terms of birth weight, gestational age at birth, and base-line risk factors for fungal infection. During the six-week treatment period, fungal colonization was documented in 30 infants in the placebo group (60 percent) and 11 infants in the fluconazole group (22 percent; difference in risk, 0.38; 95 percent confidence interval, 0.18 to 0.56; P=0.002). Invasive fungal infection with positive growth of fungal isolates from the blood, urine, or cerebrospinal fluid developed in 10 infants in the placebo group (20 percent) and none of the infants in the fluconazole group (difference in risk, 0.20; 95 percent confidence interval, 0.04 to 0.36; P=0.008). The sensitivities of the fungal isolates to fluconazole did not change during the study, and no adverse effects of the fluconazole therapy were documented. Prophylactic administration of fluconazole during the first six weeks of life is effective in preventing fungal colonization and invasive fungal infection in infants with birth weights of less than 1000 g. Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight infants. We conducted a prospective, randomized, double-blind clinical trial over a 30-month period in 100 preterm infants with birth weights of less than 1000 g. The infants were randomly assigned during the first five days of life to receive either intravenous fluconazole or placebo for six weeks. We obtained weekly surveillance cultures from all patients. The 50 infants randomly assigned to fluconazole and the 50 control infants were similar in terms of birth weight, gestational age at birth, and base-line risk factors for fungal infection. During the six-week treatment period, fungal colonization was documented in 30 infants in the placebo group (60 percent) and 11 infants in the fluconazole group (22 percent; difference in risk, 0.38; 95 percent confidence interval, 0.18 to 0.56; P=0.002). Invasive fungal infection with positive growth of fungal isolates from the blood, urine, or cerebrospinal fluid developed in 10 infants in the placebo group (20 percent) and none of the infants in the fluconazole group (difference in risk, 0.20; 95 percent confidence interval, 0.04 to 0.36; P=0.008). The sensitivities of the fungal isolates to fluconazole did not change during the study, and no adverse effects of the fluconazole therapy were documented. Prophylactic administration of fluconazole during the first six weeks of life is effective in preventing fungal colonization and invasive fungal infection in infants with birth weights of less than 1000 g. |
| Author | Kaufman, David Hazen, Kevin C Robinson, Melinda Donowitz, Leigh Goodman Boyle, Robert Patrie, James T |
| Author_xml | – sequence: 1 givenname: David surname: Kaufman fullname: Kaufman, David – sequence: 2 givenname: Robert surname: Boyle fullname: Boyle, Robert – sequence: 3 givenname: Kevin C surname: Hazen fullname: Hazen, Kevin C – sequence: 4 givenname: James T surname: Patrie fullname: Patrie, James T – sequence: 5 givenname: Melinda surname: Robinson fullname: Robinson, Melinda – sequence: 6 givenname: Leigh Goodman surname: Donowitz fullname: Donowitz, Leigh Goodman |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14120079$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11759644$$D View this record in MEDLINE/PubMed |
| BookMark | eNpt0UtLxDAQAOAgivvQm2cpop6sJk36yFGWXR_4OqznMk3TtUuarEkLur_e6BZWxFxChi8zw8wI7WqjJUJHBF8SHCdXT9P7RwOYYMbZDhqSmNKQMZzsoiHGURaylNMBGjm3xP4QxvfRgJA05gljQzSfqU4YDWujZPBizertU8FH7QJYQK1dG8w6vQAVTIwyul5DWxsdgC6DO11J8fOqtf8oW2mb7yDo1h2gvQqUk4f9PUavs-l8chs-PN_cTa4fQuGbbEMR0TSjPGUxTX1HRUxBJrwoOZc-UGRxgaNKRgVUXGIoScWAVUUJosxKlng-RuebvCtr3jvp2rypnZBKgZamcznJIsJZQjw8-QOXprPa95ZHEeU08_U9utggYY1zVlb5ytYN2M-c4Px71PnvUXt-3OfsikaWW9zP1oOzHoAToCoLWtRu6xiJMPbLGaPTjWsal2u5bP6v9wVAe5N9 |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1016_j_clp_2014_10_008 crossref_primary_10_1016_j_jpeds_2005_02_021 crossref_primary_10_1016_j_jpeds_2005_02_020 crossref_primary_10_1515_JPM_2007_055 crossref_primary_10_4103_0255_0857_99484 crossref_primary_10_1007_s40262_014_0169_7 crossref_primary_10_1016_j_clp_2014_10_010 crossref_primary_10_1542_peds_2013_0671 crossref_primary_10_1016_j_clp_2014_10_012 crossref_primary_10_1016_j_earlhumdev_2011_01_016 crossref_primary_10_1128_CMR_00076_09 crossref_primary_10_3233_NPM_17121 crossref_primary_10_1016_j_earlhumdev_2011_01_013 crossref_primary_10_1097_CCM_0b013e31826a409c crossref_primary_10_1542_peds_112_3_634 crossref_primary_10_1111_j_1442_200X_2012_03574_x crossref_primary_10_1542_peds_2009_3412 crossref_primary_10_1056_NEJMe078078 crossref_primary_10_1542_peds_2008_3008 crossref_primary_10_1016_j_riam_2013_06_002 crossref_primary_10_32429_jkshp_2014_31_4_005 crossref_primary_10_1007_s12281_011_0046_x crossref_primary_10_1542_neo_12_7_e381 crossref_primary_10_1128_CMR_00029_06 crossref_primary_10_1155_2009_274768 crossref_primary_10_1038_s41372_023_01699_0 crossref_primary_10_1038_sj_jp_7211878 crossref_primary_10_1185_03007995_2010_487799 crossref_primary_10_1097_00008480_200302000_00016 crossref_primary_10_1016_j_diagmicrobio_2006_03_013 crossref_primary_10_1097_01_PCC_0000200946_30263_B6 crossref_primary_10_1016_S0035_3787_05_85143_4 crossref_primary_10_1038_sj_jp_7211077 crossref_primary_10_1016_j_jmii_2012_07_013 crossref_primary_10_1157_13094277 crossref_primary_10_1371_journal_pone_0295528 crossref_primary_10_1016_j_siny_2015_08_003 crossref_primary_10_3389_fmicb_2016_01629 crossref_primary_10_1016_S0929_693X_11_70937_X crossref_primary_10_1128_JCM_43_6_2729_2735_2005 crossref_primary_10_1186_s40748_017_0043_3 crossref_primary_10_1097_INF_0000000000001913 crossref_primary_10_1097_MOP_0b013e3282f1dde9 crossref_primary_10_1097_INF_0b013e3181b076b1 crossref_primary_10_1097_01_inf_0000226978_96218_e6 crossref_primary_10_1016_j_clp_2007_11_014 crossref_primary_10_1016_j_pcl_2012_12_003 crossref_primary_10_1128_CMR_00013_08 crossref_primary_10_1007_s10096_004_1210_9 crossref_primary_10_1016_j_jpeds_2013_04_034 crossref_primary_10_1586_14787210_2013_811925 crossref_primary_10_1111_j_1651_2227_2008_00687_x crossref_primary_10_1128_JCM_00496_17 crossref_primary_10_1186_s12866_023_03128_w crossref_primary_10_1016_S0065_3101_23_00059_2 crossref_primary_10_1111_bcp_12025 crossref_primary_10_3164_jcbn_18_74 crossref_primary_10_1016_j_clp_2023_02_001 crossref_primary_10_3390_jof4040115 crossref_primary_10_1016_S1283_0771_10_70266_8 crossref_primary_10_1542_peds_2008_2055 crossref_primary_10_1586_14787210_6_4_393 crossref_primary_10_1053_siny_2002_9125 crossref_primary_10_1053_j_semperi_2012_06_003 crossref_primary_10_1007_s00228_012_1468_2 crossref_primary_10_1016_S0378_3782_14_70026_X crossref_primary_10_1056_NEJM200206133462415 crossref_primary_10_1542_peds_2004_2227 crossref_primary_10_1007_s12281_012_0113_y crossref_primary_10_5385_nm_2013_20_3_369 crossref_primary_10_1016_j_addr_2014_01_002 crossref_primary_10_1542_peds_2007_1130 crossref_primary_10_1111_1469_0691_12040 crossref_primary_10_1111_j_1469_0691_2010_03334_x crossref_primary_10_1038_s41598_021_00120_0 crossref_primary_10_1128_AAC_00963_16 crossref_primary_10_5385_nm_2013_20_3_361 crossref_primary_10_1016_j_diagmicrobio_2006_10_018 crossref_primary_10_1111_j_1440_1754_2010_01934_x crossref_primary_10_3389_fmicb_2021_676622 crossref_primary_10_1111_j_1470_9465_2004_00847_x crossref_primary_10_1586_eri_12_74 crossref_primary_10_1186_s12887_016_0605_y crossref_primary_10_1097_INF_0b013e31817fce78 crossref_primary_10_1186_s13052_017_0354_z crossref_primary_10_1586_eri_09_129 crossref_primary_10_1097_INF_0b013e31819693ac crossref_primary_10_1542_neo_16_4_e211 crossref_primary_10_1542_peds_2004_2292 crossref_primary_10_1093_jpids_piy009 crossref_primary_10_5863_1551_6776_16_4_237 crossref_primary_10_1038_clpt_2009_175 crossref_primary_10_3390_pathogens11020242 crossref_primary_10_5812_jjm_11858 crossref_primary_10_1016_j_jpeds_2021_10_015 crossref_primary_10_1517_13543784_13_6_665 crossref_primary_10_5812_pedinfect_21234 crossref_primary_10_3390_microorganisms8101510 crossref_primary_10_5863_1551_6776_26_2_115 crossref_primary_10_1016_j_pcl_2005_02_009 crossref_primary_10_1097_QCO_0b013e32834592e6 crossref_primary_10_1016_j_jhin_2008_01_011 crossref_primary_10_1080_14767058_2017_1416083 crossref_primary_10_3389_fped_2017_00054 crossref_primary_10_3109_00365548_2013_814150 crossref_primary_10_32677_IJCH_2016_v03_i01_011 crossref_primary_10_1038_jp_2008_38 crossref_primary_10_1111_j_1440_1754_2012_02543_x crossref_primary_10_1097_QCO_0b013e3282f1bec9 crossref_primary_10_1007_s00431_012_1760_2 crossref_primary_10_1016_j_jmii_2015_08_023 crossref_primary_10_1097_INF_0b013e31825d3091 crossref_primary_10_1016_j_ynpm_2011_07_054 crossref_primary_10_1016_S0378_3782_12_70005_1 crossref_primary_10_4236_crcm_2013_25084 crossref_primary_10_1203_01_PDR_0000112161_48023_86 crossref_primary_10_1186_s12879_016_1645_5 crossref_primary_10_1080_00365540701477550 crossref_primary_10_1086_502469 crossref_primary_10_1016_j_clp_2010_06_004 crossref_primary_10_1016_j_clp_2010_06_003 crossref_primary_10_1007_s00383_016_3940_z crossref_primary_10_4236_pp_2016_712053 crossref_primary_10_1016_S0378_3782_12_70017_8 crossref_primary_10_1542_neo_4_3_e81 crossref_primary_10_3109_14767058_2011_604934 crossref_primary_10_3345_kjp_2013_56_2_68 crossref_primary_10_1016_j_jhin_2004_04_010 crossref_primary_10_1007_s10096_006_0114_2 crossref_primary_10_1016_j_clinthera_2010_02_016 crossref_primary_10_1002_14651858_CD003850_pub5 crossref_primary_10_1097_QCO_0b013e328343614e crossref_primary_10_1542_neo_3_12_e249 crossref_primary_10_3345_cep_2019_01431 crossref_primary_10_1053_j_semperi_2007_01_006 crossref_primary_10_1080_17425255_2020_1773793 crossref_primary_10_1016_j_pedneo_2012_01_004 crossref_primary_10_1016_j_diagmicrobio_2006_07_008 crossref_primary_10_1016_S0146_0005_03_00059_4 crossref_primary_10_1097_MPG_0000000000002549 crossref_primary_10_1111_j_1442_200X_2010_03286_x crossref_primary_10_1111_j_1442_200X_2008_02726_x crossref_primary_10_3389_fped_2019_00375 crossref_primary_10_1097_01_CCM_0000208357_05675_C3 crossref_primary_10_1097_INF_0b013e318170bb0c crossref_primary_10_1097_INF_0b013e31819f1f50 crossref_primary_10_1016_S0140_6736_24_00495_1 crossref_primary_10_1542_peds_2011_3620 crossref_primary_10_3390_jof7090760 crossref_primary_10_1016_j_idc_2005_05_007 crossref_primary_10_1097_INF_0000000000001068 crossref_primary_10_1111_apa_12613 crossref_primary_10_1016_S0146_0005_03_00061_2 crossref_primary_10_1038_s41390_021_01842_7 crossref_primary_10_1016_j_yadr_2007_07_012 crossref_primary_10_1016_S1473_3099_03_00831_4 crossref_primary_10_34084_bshr_487845 crossref_primary_10_1016_j_ajic_2015_07_011 crossref_primary_10_1016_j_jpeds_2005_04_033 crossref_primary_10_1097_QCO_0b013e3283321ccc crossref_primary_10_1542_peds_2005_1969 crossref_primary_10_1111_myc_12021 crossref_primary_10_1016_S0246_0289_10_50741_2 crossref_primary_10_1016_j_earlhumdev_2010_01_012 crossref_primary_10_1038_jp_2011_27 crossref_primary_10_1080_08035250410022341 crossref_primary_10_1007_s12281_018_0312_2 crossref_primary_10_1097_01_mop_0000193300_25141_c5 crossref_primary_10_1016_j_clp_2019_02_007 crossref_primary_10_1016_S0378_3782_12_70014_2 crossref_primary_10_1016_j_jinf_2013_09_011 crossref_primary_10_1556_AMicr_57_2010_4_7 crossref_primary_10_1016_j_jpeds_2010_11_002 crossref_primary_10_1016_j_jaad_2013_09_009 crossref_primary_10_3345_kjp_2007_50_7_636 crossref_primary_10_1097_INF_0000000000001996 crossref_primary_10_1038_sj_jp_7211914 crossref_primary_10_1093_jac_dky353 crossref_primary_10_1016_j_pedneo_2016_06_001 crossref_primary_10_1111_myc_12268 crossref_primary_10_1097_INF_0000000000002042 crossref_primary_10_1007_s11046_011_9429_3 crossref_primary_10_1097_00132582_200212000_00001 crossref_primary_10_1093_jac_dki473 crossref_primary_10_1128_JCM_41_12_5623_5632_2003 crossref_primary_10_1016_j_jinf_2014_07_012 crossref_primary_10_1097_00001432_200208000_00003 crossref_primary_10_1097_INF_0b013e3181bf8eb1 crossref_primary_10_1517_14656566_8_15_2465 crossref_primary_10_1128_JCM_00946_09 crossref_primary_10_1097_INF_0b013e31817eeee5 crossref_primary_10_1097_INF_0b013e3182140a6a crossref_primary_10_1007_s00103_007_0337_0 crossref_primary_10_1016_S0146_0005_03_00060_0 crossref_primary_10_1093_cid_civ933 crossref_primary_10_1128_JCM_42_4_1519_1527_2004 crossref_primary_10_1891_0730_0832_29_5_323 crossref_primary_10_1345_aph_1M364 crossref_primary_10_1086_504324 crossref_primary_10_1111_j_1651_2227_2005_tb01791_x crossref_primary_10_1016_j_jpeds_2005_04_016 crossref_primary_10_1016_j_riam_2013_05_012 crossref_primary_10_3390_jcm11010260 crossref_primary_10_1056_NEJMoa065733 crossref_primary_10_1016_j_jhin_2004_07_020 crossref_primary_10_1097_01_inf_0000245103_07614_e1 crossref_primary_10_1007_s11096_005_7909_6 crossref_primary_10_1038_sj_jp_7211570 crossref_primary_10_3109_10408410903213393 crossref_primary_10_2165_00148581_200709050_00004 crossref_primary_10_1517_14740338_4_4_745 crossref_primary_10_1542_peds_2006_1311 crossref_primary_10_1542_peds_2011_0279 crossref_primary_10_1038_jp_2009_72 crossref_primary_10_1590_S0037_86822003000500010 crossref_primary_10_1016_j_jpeds_2012_01_053 crossref_primary_10_5385_jksn_2012_19_4_237 crossref_primary_10_3390_pathogens10030319 crossref_primary_10_1111_j_1439_0507_2006_01274_x crossref_primary_10_1517_14656566_2015_1013936 crossref_primary_10_1111_apa_13719 crossref_primary_10_1186_s13052_023_01460_5 crossref_primary_10_1007_s12519_010_0030_5 crossref_primary_10_1517_14656566_2015_1031108 crossref_primary_10_1891_0730_0832_31_2_109 crossref_primary_10_1016_j_clp_2008_09_005 crossref_primary_10_1542_peds_2005_1996 crossref_primary_10_1007_s12281_013_0172_8 crossref_primary_10_1002_14651858_CD006068_pub3 crossref_primary_10_1016_j_adnc_2006_01_005 crossref_primary_10_1016_S0123_9392_12_70031_0 crossref_primary_10_1016_j_jinf_2006_11_017 crossref_primary_10_1097_MOP_0000000000000060 crossref_primary_10_1128_AAC_01960_18 crossref_primary_10_2217_17455111_2_1_79 crossref_primary_10_1007_s12281_013_0134_1 crossref_primary_10_1016_j_jpeds_2017_02_039 crossref_primary_10_1097_01_inf_0000168751_11375_d6 crossref_primary_10_1016_j_jhin_2006_12_004 crossref_primary_10_1086_496922 crossref_primary_10_1097_01_inf_0000128777_22022_47 crossref_primary_10_1586_14787210_4_5_861 crossref_primary_10_1097_INF_0b013e3181e9dea2 crossref_primary_10_1056_NEJMc071984 crossref_primary_10_1111_jhn_12634 crossref_primary_10_3109_14767058_2015_1013933 crossref_primary_10_1016_j_bjid_2017_01_008 crossref_primary_10_1016_j_idc_2006_06_006 crossref_primary_10_1038_clpt_2009_212 crossref_primary_10_1002_jps_24181 crossref_primary_10_1093_cid_ciw363 crossref_primary_10_1016_j_arcped_2016_05_018 crossref_primary_10_1016_j_jhin_2003_08_012 crossref_primary_10_1128_CMR_17_3_638_680_2004 crossref_primary_10_1016_S0146_0005_03_00067_3 crossref_primary_10_1097_01_mpg_0000302971_06115_15 crossref_primary_10_1155_2013_413874 crossref_primary_10_1542_peds_2006_0446 crossref_primary_10_1097_00001432_200406000_00014 crossref_primary_10_1007_s00431_011_1565_8 crossref_primary_10_1016_j_cegh_2012_12_002 crossref_primary_10_1099_jmm_0_000645 crossref_primary_10_1111_j_1651_2227_2004_tb02695_x crossref_primary_10_13181_mji_v25i3_1444 crossref_primary_10_3233_NPM_200513 crossref_primary_10_1093_cid_cir800 crossref_primary_10_1097_INF_0b013e3182863a1c crossref_primary_10_1086_596757 crossref_primary_10_1016_j_ynpm_2012_06_074 crossref_primary_10_4081_pr_2011_e14 crossref_primary_10_1086_380796 crossref_primary_10_1016_j_jpeds_2005_03_036 crossref_primary_10_1038_clpt_2009_200 crossref_primary_10_1128_AAC_01298_06 crossref_primary_10_1097_INF_0b013e3181a0cfd1 crossref_primary_10_1177_001857870203700903 crossref_primary_10_1016_j_jhin_2022_09_018 crossref_primary_10_1542_peds_2005_2183 crossref_primary_10_1016_j_mycmed_2006_09_001 crossref_primary_10_1016_j_mycmed_2017_04_005 crossref_primary_10_1007_s00431_013_2041_4 crossref_primary_10_1542_peds_2015_3387 crossref_primary_10_2217_17460913_3_4_463 crossref_primary_10_1007_s00431_011_1514_6 crossref_primary_10_15585_mmwr_ss6808a1 crossref_primary_10_1111_jphp_12411 crossref_primary_10_1136_bmjopen_2012_000992 crossref_primary_10_1016_j_siny_2022_101345 crossref_primary_10_1128_AAC_48_7_2471_2476_2004 crossref_primary_10_1086_513196 crossref_primary_10_1186_s12887_020_02074_0 crossref_primary_10_1007_s00430_014_0337_2 crossref_primary_10_1038_sj_jp_7211125 crossref_primary_10_1007_s00210_024_03184_7 crossref_primary_10_1097_INF_0b013e3181e0ccc0 crossref_primary_10_1097_INF_0b013e3182769603 crossref_primary_10_3390_jof9020164 crossref_primary_10_1016_j_drup_2005_04_007 crossref_primary_10_1016_S0213_005X_03_72964_4 crossref_primary_10_5385_jksn_2012_19_2_53 crossref_primary_10_1007_s12281_013_0167_5 crossref_primary_10_1097_PCC_0b013e31829f5d88 crossref_primary_10_14776_kjpid_2011_18_1_15 crossref_primary_10_1542_neo_9_12_e562 crossref_primary_10_1097_MOP_0b013e3282f79c48 crossref_primary_10_1111_j_1469_0691_2009_02909_x crossref_primary_10_1203_PDR_0b013e318206fd3e crossref_primary_10_1016_j_disamonth_2009_03_014 crossref_primary_10_1016_S1280_4703_10_70439_4 crossref_primary_10_1097_ANC_0000000000000170 crossref_primary_10_1517_14656566_2012_647685 crossref_primary_10_1111_myc_12368 crossref_primary_10_1007_s00431_006_0088_1 crossref_primary_10_1097_01_inf_0000202127_43695_06 crossref_primary_10_1177_0091270009337513 crossref_primary_10_1016_j_clp_2011_12_008 crossref_primary_10_1111_j_1469_0691_2006_01606_x crossref_primary_10_1542_peds_2008_1837 crossref_primary_10_3390_microorganisms11040909 crossref_primary_10_1128_AAC_49_12_5092_5098_2005 crossref_primary_10_1542_peds_112_3_543 crossref_primary_10_1097_QCO_0b013e3282f8adab |
| Cites_doi | 10.1086/315193 10.1111/j.1439-0507.1998.tb00364.x 10.1542/peds.78.2.225 10.1093/infdis/172.6.1620 10.1093/clinids/22.5.803 10.1016/S0022-3476(96)70191-9 10.1038/clpt.1993.147 10.1093/jac/25.5.803 10.1016/S0095-5108(18)30523-2 10.1056/NEJM199203263261301 10.1093/infdis/171.6.1545 10.1016/S0732-8893(98)00160-6 10.1182/blood.V96.6.2055 10.1159/000239588 10.2307/2287464 10.1128/AAC.36.10.2239 10.7326/0003-4819-118-7-199304010-00003 10.1056/NEJM199503163321102 10.1111/j.1439-0507.1989.tb02180.x 10.1007/BF01974613 10.1136/adc.50.1.72 10.1111/j.1365-2885.1997.tb00093.x 10.1016/S0002-9343(95)00010-0 10.1093/infdis/174.3.583 10.1136/bmj.314.7089.1238 10.1128/AAC.42.12.3242 10.1542/peds.104.5.e63 10.1001/archsurg.1997.01430350047008 10.1093/ajhp/56.6.525 10.2307/2290928 10.1542/peds.107.2.293 10.1128/JCM.32.4.1115-1118.1994 10.1128/AAC.39.1.1 10.1007/BF02560505 10.1002/1097-0142(20001001)89:7<1611::AID-CNCR27>3.0.CO;2-B 10.1111/j.1574-6968.2000.tb08938.x 10.1002/(SICI)1097-0142(19980715)83:2<291::AID-CNCR13>3.3.CO;2-C |
| ContentType | Journal Article |
| Copyright | Copyright © 2001 Massachusetts Medical Society. All rights reserved. 2002 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2001 Massachusetts Medical Society. All rights reserved. – notice: 2002 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 0TZ 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PQEST PQQKQ PQUKI PRINS PSYQQ Q9U M7N |
| DOI | 10.1056/NEJMoa010494 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Pharma and Biotech Premium PRO ProQuest Nursing & Allied Health Database Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection ProQuest Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central British Nursing Database ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection (Proquest) (PQ_SDU_P3) New England Journal of Medicine Biological Sciences ProQuest Consumer Health Database Healthcare Administration Database PML(ProQuest Medical Library) Psychology Database (ProQuest) ProQuest research library ProQuest Science Journals Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic Algology Mycology and Protozoology Abstracts (Microbiology C) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Psychology Pharma and Biotech Premium PRO Research Library Prep ProQuest Central Student ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Research Library ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic Algology Mycology and Protozoology Abstracts (Microbiology C) |
| DatabaseTitleList | ProQuest One Psychology MEDLINE Algology Mycology and Protozoology Abstracts (Microbiology C) |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 1666 |
| ExternalDocumentID | 93538475 10_1056_NEJMoa010494 11759644 14120079 NJ200112063452303 |
| Genre | Original Article Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article General Information |
| GroupedDBID | - 08R 0R 0WA 123 186 1AW 1KJ 1VV 29N 2KS 2WC 34G 39C 3O- 3V. 4 4.4 53G 55 5D0 5RE 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8RP AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AASXA AAUTI AAWTL ABACO ABEFU ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQES ABQIJ ABUFD ABUWG ABWJO ACDCL ACGFS ACGOD ACJLH ACNCT ACPRK ACPVT ACRZS ACTDY ACVYA ADBBV ADCBC AENEX AETEA AFDAS AFFDN AFFNX AFKRA AFMIJ AGNAY AHMBA AHVBC AIKQT AJJEV AJUXI AJYGW ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCR BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F20 F5P FD8 FM. FYUFA G8K GJ GNUQQ GUQSH HCIFZ HZ IH2 J5H K-O K78 KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC MVM N9A NEJ O0- O9- OHM OHT OK1 OMK OVD P-O P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO QZG RHI RWL RXW S6N SJFOW SJN SKT TAE TAF TN5 TWZ U1N UCV UKR VQA W2G WH7 WOQ WOW X X7M XFK XJT XYN XZL YCJ YHZ YNT YZZ ZA5 ZGI ZHY ZKB ZKG ZXP --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 1CY 36B 41~ 68V 6TJ 8WZ 9M8 A6W AAJWC AAMNW AAUGY AAYOK ABCQX ACKOT ACPFK ADRHT AFHKK AFOSN AGFXO AGHSJ AKALU CCPQU D0S FA8 H13 HF~ HZ~ I4R IQODW MQT N4W NAPCQ NHB PSYQQ QJJ S10 TEORI TUQ UBX UKHRP UMD UQL WHG XOL YFH YQI YQJ YR2 YRY YYP YYQ ZCA ZR0 ZVN ~KM ABBLC ADUKH AERZD ALIPV CGR CUY CVF ECM EIF NPM UIG AAYXX ABDPE CITATION HMCUK 0TZ 7XB BEC K0Y Q9U M7N |
| ID | FETCH-LOGICAL-c533t-c23783974537117b53ae69bd99e371b85b02fe2baf9e0ad1f4a4fbdacd8d46b53 |
| ISSN | 0028-4793 |
| IngestDate | Fri Oct 25 00:18:21 EDT 2024 Thu Oct 10 17:51:00 EDT 2024 Thu Nov 21 23:53:52 EST 2024 Sat Sep 28 07:43:36 EDT 2024 Sun Oct 22 16:07:58 EDT 2023 Wed Nov 11 00:33:00 EST 2020 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 23 |
| Keywords | Human Infection Premature Prevention Antifungal agent Chemotherapy Newborn Fluconazole Mycosis Triazole derivatives Extremely low birthweight Colonization |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c533t-c23783974537117b53ae69bd99e371b85b02fe2baf9e0ad1f4a4fbdacd8d46b53 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.nejm.org/doi/pdf/10.1056/NEJMoa010494?articleTools=true |
| PMID | 11759644 |
| PQID | 223938711 |
| PQPubID | 40644 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_18219461 proquest_journals_223938711 crossref_primary_10_1056_NEJMoa010494 pubmed_primary_11759644 pascalfrancis_primary_14120079 mms_nejm_10_1056_NEJMoa010494 |
| ProviderPackageCode | DCD 7FN |
| PublicationCentury | 2000 |
| PublicationDate | 2001-12-06 |
| PublicationDateYYYYMMDD | 2001-12-06 |
| PublicationDate_xml | – month: 12 year: 2001 text: 2001-12-06 day: 06 |
| PublicationDecade | 2000 |
| PublicationPlace | Boston, MA |
| PublicationPlace_xml | – name: Boston, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 2001 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | Kern, W, Behre, G, Rudolf, T (r029) 1998; 83 Slavin, MA, Osborne, B, Adams, R (r009) 1995; 171 Santner, TJ, Snell, MK (r027) 1980; 75 Marr, KA, Seidel, K, White, TC, Bowden, RA (r013) 2000; 181 Berger, RL, Boos, DD (r026) 1994; 89 Hazen, KC, Mandell, G, Coleman, E, Wu, G (r035) 2000; 183 Kicklighter, SD, Springer, SC, Cox, T, Hulsey, TC, Turner, RB (r005) 2001; 107 Reference method for broth dilution antifungal susceptibility testing of yeasts: approved standard. Wayne, Pa.: National Committee of Clinical Laboratory Standards, 1997. (NCCLS document no. M27-A.) Abu-el Teen, K, Ghannoum, M, Stretton, RJ (r034) 1989; 32 Stoll, BJ, Temprosa, M, Tyson, JE (r004) 1999; 104 Xanthou, M, Valassi-Adam, E, Kintsonidou, E, Matsaniotis, N (r006) 1975; 50 Lewis, RE, Klepser, ME (r015) 1999; 56 Gleason, TG, May, AK, Caparelli, D, Farr, BM, Sawyer, RG (r033) 1997; 132 Winston, DJ, Chandrasekar, PH, Lazarus, HM (r008) 1993; 118 Garcha, UK, Brummer, E, Stevens, DA (r038) 1995; 172 Murray PR, ed. Manual of clinical microbiology. 7th ed. Washington, D.C.: ASM Press, 1999:1191-7. Minguez Minguez, F, Lima, JE, Garcia, MT, Prieto, J (r039) 1997; 43 Pfaller, MA, Messer, SA, Hollis, RJ (r016) 1999; 33 Van 't Wout, JW, Meynaar, I, Linde, I, Poell, R, Mattie, H, Van Furth, R (r037) 1990; 25 Powderly, WG, Finkelstein, D, Feinberg, J (r010) 1995; 332 Nguyen, MH, Peacock, JE, Morris, AJ (r018) 1996; 100 Baley, JE, Kliegman, RM, Boxerbaum, B, Fanaroff, AA (r003) 1986; 78 Brammer, KW, Coates, PE (r020) 1994; 13 Mucke, R, Kaben, U, Libera, T (r012) 1998; 41 Marr, KA, Seidel, K, Slavin, MA (r030) 2000; 96 Pfaller, MA, Messer, SA, Hollis, RJ (r040) 1998; 42 Ghannoum, MA, Filler, SG, Ibrahim, AS, Fu, Y, Edwards, JE (r036) 1992; 36 Diggle PJ, Liang K-Y, Zeger SL. Analysis of longitudinal data. Oxford, England: Clarendon Press, 1994:143-5. Lumbreras, C, Cuervas-Mons, V, Jara, P (r011) 1996; 174 Saxen, H, Hoppu, K, Pohjavuori, M (r019) 1993; 54 Hennekens CH, Buring JE. Epidemiology in medicine. 2nd ed. Boston: Little, Brown, 1994:87-8. Stoll, BJ, Gordon, T, Korones, SB (r001) 1996; 129 Baley, JE (r002) 1991; 18 Goodman, JL, Winston, DJ, Greenfield, RA (r007) 1992; 326 Waggoner-Fountain, LA, Walker, MW, Hollis, RJ (r042) 1996; 22 Rex, JH, Rinaldi, MG, Pfaller, MA (r017) 1995; 39 Mehta C, Patel N. Proc-StatXact 4 for SAS users. Cambridge, Mass.: Cytel Software, 1999:257-92. Huang, YC, Lin, TY, Leu, HS, Peng, HL, Wu, JH, Chang, HY (r043) 1999; 27 Vaden, SL, Heit, MC, Hawkins, EC, Manaugh, C, Riviere, JE (r041) 1997; 20 Gotzsche, PC, Johansen, HK (r031) 1997; 314 Kanda, Y, Yamamoto, R, Chizuka, A (r032) 2000; 89 Spicer, AD, Hazen, KC (r021) 1992; 1 Millon, L, Manteaux, A, Reboux, G (r014) 1994; 32 12066811 - N Engl J Med. 2002 Jun 13;346(24):1913-4; author reply 1913-4 12063380 - N Engl J Med. 2002 Jun 13;346(24):1913-4; author reply 1913-4 Ghannoum MA (r036) 1992; 36 r020 r042 r043 r022 r001 r023 Gleason TG (r033) 1997; 132 Lewis RE (r015) 1999; 56 Gotzsche PC (r031) 1997; 314 r041 r039 r018 r019 r013 r035 Rex JH (r017) 1995; 39 r037 r016 r038 Winston DJ (r008) 1993; 118 Spicer AD (r021) 1992; 1 Pfaller MA (r040) 1998; 42 Baley JE (r002) 1991; 18 Millon L (r014) 1994; 32 r010 r032 r011 r012 r034 r006 r028 r007 r029 Marr KA (r030) 2000; 96 r009 r024 r004 r026 r005 r027 Baley JE (r003) 1986; 78 |
| References_xml | – volume: 89 start-page: 1012 year: 1994 end-page: 1016 ident: r026 article-title: P values maximized over a confidence set for the nuisance parameter. publication-title: J Am Stat Assoc contributor: fullname: Boos, DD – volume: 75 start-page: 386 year: 1980 end-page: 394 ident: r027 article-title: Small-sample confidence intervals for p1-p2 and p1 /p2 in 2×2 contingency tables. publication-title: J Am Stat Assoc contributor: fullname: Snell, MK – volume: 56 start-page: 525 year: 1999 end-page: 533 ident: r015 article-title: The changing face of nosocomial candidemia: epidemiology, resistance, and drug therapy. publication-title: Am J Health Syst Pharm contributor: fullname: Klepser, ME – volume: 332 start-page: 700 year: 1995 end-page: 705 ident: r010 article-title: A randomized trial comparing fluconazole with clotrimazole troches for the prevention of fungal infections in patients with advanced human immunodeficiency virus infection. publication-title: N Engl J Med contributor: fullname: Feinberg, J – volume: 27 start-page: 97 year: 1999 end-page: 102 ident: r043 article-title: Outbreak of Candida parapsilosis fungemia in neonatal intensive care units: clinical implications and genotyping analysis. publication-title: Infection contributor: fullname: Chang, HY – volume: 78 start-page: 225 year: 1986 end-page: 232 ident: r003 article-title: Fungal colonization in the very low birth weight infant. publication-title: Pediatrics contributor: fullname: Fanaroff, AA – volume: 181 start-page: 309 year: 2000 end-page: 316 ident: r013 article-title: Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole. publication-title: J Infect Dis contributor: fullname: Bowden, RA – volume: 20 start-page: 181 year: 1997 end-page: 186 ident: r041 article-title: Fluconazole in cats: pharmacokinetics following intravenous and oral administration and penetration into cerebrospinal fluid, aqueous humour andpulmonary epithelial lining fluid. publication-title: J Vet Pharmacol Ther contributor: fullname: Riviere, JE – volume: 1 start-page: 284 year: 1992 end-page: 289 ident: r021 article-title: Rapid confirmation of Candida albicans identification by combination of two presumptive tests. publication-title: Med Microbiol Lett contributor: fullname: Hazen, KC – volume: 13 start-page: 325 year: 1994 end-page: 329 ident: r020 article-title: Pharmacokinetics of fluconazole in pediatric patients. publication-title: Eur J Clin Microbiol Infect Dis contributor: fullname: Coates, PE – volume: 83 start-page: 291 year: 1998 end-page: 301 ident: r029 article-title: Failure of fluconazole prophylaxis to reduce mortality or the requirement of systemic amphotericin B therapy during treatment for refractory acute myeloid leukemia: results of a prospective randomized phase III study. publication-title: Cancer contributor: fullname: Rudolf, T – volume: 89 start-page: 1611 year: 2000 end-page: 1625 ident: r032 article-title: Prophylactic action of oral fluconazole against fungal infection in neutropenic patients: a meta-analysis of 16 randomized, controlled trials. publication-title: Cancer contributor: fullname: Chizuka, A – volume: 104 start-page: 1121 year: 1999 end-page: 1121 ident: r004 article-title: Dexamethasone therapy increases infection in very low birth weight infants. publication-title: Pediatrics contributor: fullname: Tyson, JE – volume: 43 start-page: 346 year: 1997 end-page: 351 ident: r039 article-title: Effects of antifungal pretreatment on the susceptibility of Candida albicans to human leukocytes. publication-title: Chemotherapy contributor: fullname: Prieto, J – volume: 107 start-page: 293 year: 2001 end-page: 298 ident: r005 article-title: Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant. publication-title: Pediatrics contributor: fullname: Turner, RB – volume: 33 start-page: 217 year: 1999 end-page: 222 ident: r016 article-title: Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States. publication-title: Diagn Microbiol Infect Dis contributor: fullname: Hollis, RJ – volume: 36 start-page: 2239 year: 1992 end-page: 2244 ident: r036 article-title: Modulation of interactions of Candida albicans and endothelial cells by fluconazole and amphotericin B. publication-title: Antimicrob Agents Chemother contributor: fullname: Edwards, JE – volume: 25 start-page: 803 year: 1990 end-page: 811 ident: r037 article-title: Effect of amphotericin B, fluconazole and itraconazole on intracellular Candida albicans and germ tube development in macrophages. publication-title: J Antimicrob Chemother contributor: fullname: Van Furth, R – volume: 50 start-page: 72 year: 1975 end-page: 75 ident: r006 article-title: Phagocytosis and killing ability of Candida albicans by blood leukocytes of healthy term and preterm babies. publication-title: Arch Dis Child contributor: fullname: Matsaniotis, N – volume: 39 start-page: 1 year: 1995 end-page: 8 ident: r017 article-title: Resistance of Candida species to fluconazole. publication-title: Antimicrob Agents Chemother contributor: fullname: Pfaller, MA – volume: 326 start-page: 845 year: 1992 end-page: 851 ident: r007 article-title: A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. publication-title: N Engl J Med contributor: fullname: Greenfield, RA – volume: 32 start-page: 1115 year: 1994 end-page: 1118 ident: r014 article-title: Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. publication-title: J Clin Microbiol contributor: fullname: Reboux, G – volume: 129 start-page: 63 year: 1996 end-page: 71 ident: r001 article-title: Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. publication-title: J Pediatr contributor: fullname: Korones, SB – volume: 314 start-page: 1238 year: 1997 end-page: 1244 ident: r031 article-title: Meta-analysis of prophylactic or empirical antifungal treatment versus placebo or no treatment in patients with cancer complicated by neutropenia. publication-title: BMJ contributor: fullname: Johansen, HK – volume: 132 start-page: 1197 year: 1997 end-page: 1202 ident: r033 article-title: Emerging evidence of selection of fluconazole-tolerant fungi in surgical intensive care units. publication-title: Arch Surg contributor: fullname: Sawyer, RG – volume: 172 start-page: 1620 year: 1995 end-page: 1623 ident: r038 article-title: Synergy of fluconazole with human monocytes or monocyte-derived macrophages for killing of Candida species. publication-title: J Infect Dis contributor: fullname: Stevens, DA – volume: 42 start-page: 3242 year: 1998 end-page: 3244 ident: r040 article-title: In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole. publication-title: Antimicrob Agents Chemother contributor: fullname: Hollis, RJ – volume: 18 start-page: 263 year: 1991 end-page: 280 ident: r002 article-title: Neonatal candidiasis: the current challenge. publication-title: Clin Perinatol contributor: fullname: Baley, JE – volume: 22 start-page: 803 year: 1996 end-page: 808 ident: r042 article-title: Vertical and horizontal transmission of unique Candida species to premature newborns. publication-title: Clin Infect Dis contributor: fullname: Hollis, RJ – volume: 171 start-page: 1545 year: 1995 end-page: 1552 ident: r009 article-title: Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation -- a prospective, randomized, double-blind study. publication-title: J Infect Dis contributor: fullname: Adams, R – volume: 100 start-page: 617 year: 1996 end-page: 623 ident: r018 article-title: The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance. publication-title: Am J Med contributor: fullname: Morris, AJ – volume: 183 start-page: 89 year: 2000 end-page: 94 ident: r035 article-title: Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans. publication-title: FEMS Microbiol Lett contributor: fullname: Wu, G – volume: 96 start-page: 2055 year: 2000 end-page: 2061 ident: r030 article-title: Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial. publication-title: Blood contributor: fullname: Slavin, MA – volume: 118 start-page: 495 year: 1993 end-page: 503 ident: r008 article-title: Fluconazole prophylaxis of fungal infections in patients with acute leukemia: results of a randomized placebo-controlled, double-blind, multicenter trial. publication-title: Ann Intern Med contributor: fullname: Lazarus, HM – volume: 41 start-page: 421 year: 1998 end-page: 423 ident: r012 article-title: Fluconazole prophylaxis in patients with head and neck tumours undergoing radiation and radiochemotherapy. publication-title: Mycoses contributor: fullname: Libera, T – volume: 174 start-page: 583 year: 1996 end-page: 588 ident: r011 article-title: Randomized trial of fluconazole versus nystatin for the prophylaxis of Candida infection following liver transplantation. publication-title: J Infect Dis contributor: fullname: Jara, P – volume: 54 start-page: 269 year: 1993 end-page: 277 ident: r019 article-title: Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of life. publication-title: Clin Pharmacol Ther contributor: fullname: Pohjavuori, M – volume: 32 start-page: 551 year: 1989 end-page: 562 ident: r034 article-title: Effects of sub-inhibitory concentrations of antifungal agents on adherence of Candida spp. to buccal epithelial cells in vitro. publication-title: Mycoses contributor: fullname: Stretton, RJ – ident: r013 doi: 10.1086/315193 – ident: r012 doi: 10.1111/j.1439-0507.1998.tb00364.x – volume: 78 start-page: 225 year: 1986 ident: r003 publication-title: Pediatrics doi: 10.1542/peds.78.2.225 contributor: fullname: Baley JE – ident: r038 doi: 10.1093/infdis/172.6.1620 – ident: r042 doi: 10.1093/clinids/22.5.803 – ident: r001 doi: 10.1016/S0022-3476(96)70191-9 – ident: r019 doi: 10.1038/clpt.1993.147 – ident: r028 – ident: r024 – ident: r037 doi: 10.1093/jac/25.5.803 – volume: 18 start-page: 263 year: 1991 ident: r002 publication-title: Clin Perinatol doi: 10.1016/S0095-5108(18)30523-2 contributor: fullname: Baley JE – ident: r007 doi: 10.1056/NEJM199203263261301 – ident: r022 – ident: r009 doi: 10.1093/infdis/171.6.1545 – ident: r016 doi: 10.1016/S0732-8893(98)00160-6 – volume: 96 start-page: 2055 year: 2000 ident: r030 publication-title: Blood doi: 10.1182/blood.V96.6.2055 contributor: fullname: Marr KA – volume: 1 start-page: 284 year: 1992 ident: r021 publication-title: Med Microbiol Lett contributor: fullname: Spicer AD – ident: r039 doi: 10.1159/000239588 – ident: r027 doi: 10.2307/2287464 – volume: 36 start-page: 2239 year: 1992 ident: r036 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.36.10.2239 contributor: fullname: Ghannoum MA – volume: 118 start-page: 495 year: 1993 ident: r008 publication-title: Ann Intern Med doi: 10.7326/0003-4819-118-7-199304010-00003 contributor: fullname: Winston DJ – ident: r010 doi: 10.1056/NEJM199503163321102 – ident: r034 doi: 10.1111/j.1439-0507.1989.tb02180.x – ident: r020 doi: 10.1007/BF01974613 – ident: r006 doi: 10.1136/adc.50.1.72 – ident: r041 doi: 10.1111/j.1365-2885.1997.tb00093.x – ident: r018 doi: 10.1016/S0002-9343(95)00010-0 – ident: r011 doi: 10.1093/infdis/174.3.583 – volume: 314 start-page: 1238 year: 1997 ident: r031 publication-title: BMJ doi: 10.1136/bmj.314.7089.1238 contributor: fullname: Gotzsche PC – volume: 42 start-page: 3242 year: 1998 ident: r040 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.42.12.3242 contributor: fullname: Pfaller MA – ident: r004 doi: 10.1542/peds.104.5.e63 – volume: 132 start-page: 1197 year: 1997 ident: r033 publication-title: Arch Surg doi: 10.1001/archsurg.1997.01430350047008 contributor: fullname: Gleason TG – ident: r023 – volume: 56 start-page: 525 year: 1999 ident: r015 publication-title: Am J Health Syst Pharm doi: 10.1093/ajhp/56.6.525 contributor: fullname: Lewis RE – ident: r026 doi: 10.2307/2290928 – ident: r005 doi: 10.1542/peds.107.2.293 – volume: 32 start-page: 1115 year: 1994 ident: r014 publication-title: J Clin Microbiol doi: 10.1128/JCM.32.4.1115-1118.1994 contributor: fullname: Millon L – volume: 39 start-page: 1 year: 1995 ident: r017 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.39.1.1 contributor: fullname: Rex JH – ident: r043 doi: 10.1007/BF02560505 – ident: r032 doi: 10.1002/1097-0142(20001001)89:7<1611::AID-CNCR27>3.0.CO;2-B – ident: r035 doi: 10.1111/j.1574-6968.2000.tb08938.x – ident: r029 doi: 10.1002/(SICI)1097-0142(19980715)83:2<291::AID-CNCR13>3.3.CO;2-C |
| SSID | ssj0000149 |
| Score | 2.3177986 |
| Snippet | Invasive fungal infections cause substantial morbidity and mortality in preterm infants. In this single-center, double-blind, placebo-controlled trial,... Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in... Background Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic... |
| SourceID | proquest crossref pubmed pascalfrancis mms |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1660 |
| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - adverse effects Antifungal Agents - therapeutic use Babies Bacterial infections Bacterial Infections - epidemiology Biological and medical sciences Birth weight Candida - drug effects Candida - isolation & purification Candida albicans - drug effects Candida albicans - isolation & purification Candidiasis - prevention & control Colony Count, Microbial Double-Blind Method Fluconazole - adverse effects Fluconazole - therapeutic use Fungal infections Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - prevention & control Infant, Very Low Birth Weight Infusions, Intravenous Intensive care Medical sciences Microbial Sensitivity Tests Mortality Mycoses - prevention & control Pharmacology. Drug treatments Prospective Studies Trichosporon - isolation & purification |
| Title | Fluconazole Prophylaxis against Fungal Colonization and Infection in Preterm Infants |
| URI | http://dx.doi.org/10.1056/NEJMoa010494 https://www.ncbi.nlm.nih.gov/pubmed/11759644 https://www.proquest.com/docview/223938711 https://search.proquest.com/docview/18219461 |
| Volume | 345 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbYIiEuiDehtPgApyoicd5HHllVfSwSTaXeIid2qlbdBJGuBP31fI6djRdRAQcuUdbZtZKZb8cz4y8zhLyppRdJrPyuYIK5WG-ZW0Wp54asbkIsH5WoVGpg_yRZnKWf8jCf-PPT2H_VNMaga_Xm7D9oez0pBnAOneMIreP4V3qfKw56y28UaxDWEVK84t8v-j1-zi_gCu5hITsfaoJcdeM7mKYCk2ZlDcxHxUKEyVaD3NR6Gj3YwpAiTfcPu_TEr_v0h3zVmATrmlf8ofuhCcxfJtt3o03f4ZSxHRoH6Oy-YXGPiQl_IHnEtrE1iTvb2Aa6eKRBFQss2-nHurOAWYfVfuZvbTxcNihhkR8cd1xFk7pJ8mYp7cXncn56dFQW-VkxI3cZ7kIZwZODhVVbzMRG5i7NWxGY_Z0994a_Mlsue8We5T3-QI3ufHJ7aDK4KMVD8sDEFvS9BsUjcke2j8m9Y6OVJ6SwsEEtbFCDDaqxQW1sUOiYrrGBM2qwQQ02npLTeV583HdNVw23hmt_7dYsSOAVJ2EUJL6fVFHAZZxVIsskBqo0qjzWSFbxJpMeF34T8rCpBK9FKsIYX39GttqulS8IbQRPa9VLM2QQppelCT5ylvmSB1ETxA55O8qu_KqLp5QD6SGKS1vGDtmBYMtWXi5vub67IfJpMtgWOLmZQ7ZHHZQG9n3JVHW_FM_okNfrqzCeakeMt7Jb9SWCaz-DSXLIc624aWa41RlihZd__O02uT-h_xXZuv62kjtk1ovV7gC4n1NJlGI |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Multiple Vendors |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fluconazole+prophylaxis+against+fungal+colonization+and+infection+in+preterm+infants&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Kaufman%2C+D&rft.au=Boyle%2C+R&rft.au=Hazen%2C+K+C&rft.au=Patrie%2C+J+T&rft.date=2001-12-06&rft.issn=0028-4793&rft.volume=345&rft.issue=23&rft.spage=1660&rft.epage=1666&rft_id=info:doi/10.1056%2FNEJMoa010494&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |