Genetic variation in adiponectin ( ) and the type 1 receptor ( ), obesity and prostate cancer in African Americans

• Published in: Prostate cancer and prostatic diseases Vol. 13; no. 4; pp. 362 - 368
• Main Authors: Beebe-Dimmer, J L, Zuhlke, K A, Ray, A M, Lange, E M, Cooney, K A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-12-2010; Nature Publishing Group
• Subjects: 631/208/726/649; 692/699/2743/393; 692/699/67/589/466; Adiponectin; Adiponectin - genetics; Adipose tissue; Adult; African Americans; African Americans - genetics; African Americans - statistics & numerical data; Aged; Biomedical and Life Sciences; Biomedicine; Body mass; Breast cancer; Cancer Research; Carcinogenesis; Carcinogens; Carcinoma - complications; Carcinoma - epidemiology; Carcinoma - ethnology; Carcinoma - genetics; Case-Control Studies; Colorectal carcinoma; Deoxyribonucleic acid; DNA; Gene Frequency; Genetic diversity; Genetic Variation - physiology; Genotype; Health risks; Humans; Male; Middle Aged; Minority & ethnic groups; Nucleotides; Obesity; Obesity - complications; Obesity - epidemiology; Obesity - genetics; original-article; Polymorphism, Single Nucleotide; Prevalence; Prostate cancer; Prostatic Neoplasms - complications; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - genetics; Receptors; Receptors, Adiponectin - genetics; Risk; Single-nucleotide polymorphism; adipokines; genetic susceptibility; single-nucleotide polymorphism; body mass index; racial differences
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/pcan.2010.27

Adiponectin is a protein derived from adipose tissue suspected to have an important role in prostate carcinogenesis. Variants in the adiponectin gene (
ADIPOQ
) and its type 1 receptor (
ADIPOR1
) have been recently linked to risk of both breast and colorectal cancer. Therefore, we set out to examine the relationship between polymorphisms in these genes, obesity and prostate cancer in study of African-American men. Ten single-nucleotide polymorphisms (SNPs) in
ADIPOQ
and
ADIPOR1
were genotyped in DNA samples from 131 African-American prostate cancer cases and 344 controls participating in the Flint Men's Health Study. Logistic regression was then used to estimate their association with prostate cancer and obesity. While no significant associations were detected between any of the tested SNPs and prostate cancer, the rs1501299 SNP in
ADIPOQ
was significantly associated with body mass (
P
=0.03). Genetic variation in
ADIPOQ
and
ADIPOR1
did not predict risk of prostate cancer in this study of African-American men. However, the rs1501299 SNP in
ADIPOQ
was associated with obesity. Further investigation is warranted to determine if racial differences exist in the influence of the adiponectin pathway on prostate cancer risk.