Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

• Published in: Maxillofacial plastic and reconstructive surgery Vol. 41; no. 1; p. 11
• Main Authors: Kim, Jae-Young, Kim, Dae-Hoon, Jang, Hyo-Won, Park, Kwang-Ho, Huh, Jong-Ki
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 04-03-2019; SpringerOpen; 대한악안면성형재건외과학회
• Subjects: Bisphosphonate; Botulinum toxin; Botulinum toxin A (BTXA) application in dentistry; Dentistry; Mandibular condyle; Medicine; Oral and Maxillofacial Surgery; Plastic Surgery; Temporomandibular joint; 치의학; Temporomandibular joint; Bisphosphonate; Mandibular condyle; Botulinum toxin
• ISSN: 2288-8101; 2288-8586; 2288-8586
• DOI: 10.1186/s40902-019-0193-5

Background
Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats.
Results
The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (
p
 = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (
p
 < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group.
Conclusion
Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.