Effect of paternal exposure to gamma rays on juvenile rat forebrain
Abstract We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control fem...
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| Published in: | Neurotoxicology and teratology Vol. 29; no. 4; pp. 521 - 526 |
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| Abstract | Abstract We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control females. To label proliferating cells, the progeny received bromodeoxyuridine (BrdU) injection before sacrifice. The number of BrdU-positive cells was counted in three parts of the forebrain RMS, i.e. in the vertical arm, elbow and horizontal arm, at the 3rd, 7th, 14th, 21st and 28th postnatal days (P3–P28). In the RMS of control rats' progeny, the number of BrdU+ cells transiently decreased at the 7th–14th postnatal days. In the progeny of irradiated rats, the dynamics of the changes was similar to that in the corresponding control groups, however, the number of BrdU-positive cells was significantly higher along the whole RMS at all intervals of investigation. These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. |
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| AbstractList | We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control females. To label proliferating cells, the progeny received bromodeoxyuridine (BrdU) injection before sacrifice. The number of BrdU-positive cells was counted in three parts of the forebrain RMS, i.e. in the vertical arm, elbow and horizontal arm, at the 3rd, 7th, 14th, 21st and 28th postnatal days (P3–P28). In the RMS of control rats' progeny, the number of BrdU
+ cells transiently decreased at the 7th–14th postnatal days. In the progeny of irradiated rats, the dynamics of the changes was similar to that in the corresponding control groups, however, the number of BrdU-positive cells was significantly higher along the whole RMS at all intervals of investigation. These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control females. To label proliferating cells, the progeny received bromodeoxyuridine (BrdU) injection before sacrifice. The number of BrdU-positive cells was counted in three parts of the forebrain RMS, i.e. in the vertical arm, elbow and horizontal arm, at the 3rd, 7th, 14th, 21st and 28th postnatal days (P3-P28). In the RMS of control rats' progeny, the number of BrdU super(+) cells transiently decreased at the 7th-14th postnatal days. In the progeny of irradiated rats, the dynamics of the changes was similar to that in the corresponding control groups, however, the number of BrdU-positive cells was significantly higher along the whole RMS at all intervals of investigation. These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control females. To label proliferating cells, the progeny received bromodeoxyuridine (BrdU) injection before sacrifice. The number of BrdU-positive cells was counted in three parts of the forebrain RMS, i.e. in the vertical arm, elbow and horizontal arm, at the 3rd, 7th, 14th, 21st and 28th postnatal days (P3-P28). In the RMS of control rats' progeny, the number of BrdU(+) cells transiently decreased at the 7th-14th postnatal days. In the progeny of irradiated rats, the dynamics of the changes was similar to that in the corresponding control groups, however, the number of BrdU-positive cells was significantly higher along the whole RMS at all intervals of investigation. These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. Abstract We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS) in the brain of neonatal and young progeny of male rats exposed to the dose of 3 Gy 25 days before conception with intact control females. To label proliferating cells, the progeny received bromodeoxyuridine (BrdU) injection before sacrifice. The number of BrdU-positive cells was counted in three parts of the forebrain RMS, i.e. in the vertical arm, elbow and horizontal arm, at the 3rd, 7th, 14th, 21st and 28th postnatal days (P3–P28). In the RMS of control rats' progeny, the number of BrdU+ cells transiently decreased at the 7th–14th postnatal days. In the progeny of irradiated rats, the dynamics of the changes was similar to that in the corresponding control groups, however, the number of BrdU-positive cells was significantly higher along the whole RMS at all intervals of investigation. These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. |
| Author | Bálentová, Soňa Račeková, Enikő Mišúrová, Eva |
| Author_xml | – sequence: 1 givenname: Sofia surname: BHLENTOVA fullname: BHLENTOVA, Sofia organization: Institute of Biological and Ecological Sciences, Faculty of Science, P. J. Šafárik University, Moyzesova 11, 040 01 Kosice, Slovakia – sequence: 2 givenname: Eniko surname: RACEKOVA fullname: RACEKOVA, Eniko organization: Institute of Neurobiology, Centre of Excellence, Slovak Academy of Sciences, Soltesovej 4, 040 01 Kosice, Slovakia – sequence: 3 givenname: Eva surname: MISUROA fullname: MISUROA, Eva organization: Institute of Biological and Ecological Sciences, Faculty of Science, P. J. Šafárik University, Moyzesova 11, 040 01 Kosice, Slovakia |
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| Cites_doi | 10.1016/S0361-9230(01)00770-5 10.1016/j.ntt.2004.10.003 10.1186/1475-2867-1-1 10.1097/01.jnen.0000190066.13312.8f 10.1016/S0963-6897(98)00009-8 10.1016/S0169-328X(01)00180-2 10.1007/s10571-006-9039-7 10.1093/mutage/16.1.17 10.1080/095530000139050 10.1269/jrr.43.125 10.1080/0955300031000096315 10.1073/pnas.102015399 10.1016/j.gde.2003.08.012 10.5566/ias.v20.p119-130 10.1016/j.mrgentox.2003.12.005 10.1038/35011135 10.1667/RR3141 10.1007/s10571-006-9067-3 10.1006/dbio.1999.9498 10.1016/S0921-8777(00)00066-5 10.1016/S0168-0102(02)00173-6 10.1006/exnr.2001.7768 10.1097/00004032-200307000-00006 10.1007/s10571-005-8191-9 10.1016/S0306-4522(00)00151-2 10.1080/095530002317577330 10.1523/JNEUROSCI.19-06-02171.1999 10.1080/095530098140952 10.1523/JNEUROSCI.17-13-05046.1997 10.1093/carcin/21.3.397 10.1016/S0167-8140(01)00285-7 10.1016/j.expneurol.2004.05.005 10.1093/carcin/21.3.379 |
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| Keywords | Neural cell proliferation Rat progeny Ionizing radiation Genomic instability Cell proliferation Rat Genomics Rodentia Nervous system Exposure Young animal Progeny Vertebrata Gamma irradiation Mammalia Instability Genome Father |
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| Snippet | Abstract We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory... We studied the transgenerational effect of the sublethal dose of gamma radiation on the proliferative activity of cells in the rostral migratory stream (RMS)... |
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| SubjectTerms | Age Factors Animals Animals, Newborn Behavior, Animal - radiation effects Biological and medical sciences Bromodeoxyuridine - metabolism Cell Count Cell Proliferation - radiation effects Emergency Female Gamma Rays - adverse effects Genomic instability Ionizing radiation Male Medical Education Medical sciences Neural cell proliferation Neurons - radiation effects Paternal Exposure Pregnancy Prosencephalon - pathology Prosencephalon - radiation effects Radiation Injuries, Experimental - pathology Rat progeny Rats Rats, Wistar Sex Factors Toxicology Whole-Body Irradiation - methods |
| Title | Effect of paternal exposure to gamma rays on juvenile rat forebrain |
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