Invasive pneumococcal disease: Association between serotype, clinical presentation and lethality

• Published in: Vaccine Vol. 29; no. 34; pp. 5740 - 5746
• Main Authors: Rodríguez, Mª Angeles Gutiérrez, González, Amai Varela, Gavín, María Ascensión Ordobás, Martínez, Fernando Martín, Marín, Natividad García, Blázquez, Belén Ramos, Moreno, Juan Carlos Sanz
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05-08-2011; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Allergy and Immunology; Applied microbiology; Bacterial diseases; Bacteriology; Biological and medical sciences; Child; Child, Preschool; childhood; children; Children & youth; Female; Fundamental and applied biological sciences. Psychology; gender; Health risks; Heptavalent pneumococcal conjugate vaccine; Human bacterial diseases; Humans; Immunization; Infant; Infectious diseases; Invasive pneumococcal disease; Male; Medical sciences; Meningitis; Microbiology; Middle Aged; Miscellaneous; Pneumococcal Infections - epidemiology; Pneumococcal Infections - immunology; Pneumococcal Infections - mortality; Pneumococcal Vaccines - immunology; Pneumonia; Population Surveillance; risk; Risk factors; Serotype; serotypes; Serotyping; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - immunology; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Heptavalent pneumococcal conjugate vaccine; Invasive pneumococcal disease; Serotype; Infection; Streptococcaceae; Streptococcal infection; Bacteriosis; Bacteria; Micrococcales; Vaccine; Pneumococcal infection; Heptavalent pneumococcal conjugate; Streptococcus pneumoniae
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.05.099

Highlights ► We reviewed 2013 invasive pneumococcal disease (IPD) cases recorded in 2007-2009. ► The mean annual incidence was 10.74 cases per 100,000 and the lethality was 8.8%. ► Serotype 3, male gender and sepsis were associated with lethality. ► Vaccinated children had a higher risk of disease due to serotype 19A. ► Serotype 8 was associated with the presence of underlying risk factors.