SCOP: A structural classification of proteins database for the investigation of sequences and structures

• Published in: Journal of molecular biology Vol. 247; no. 4; pp. 536 - 540
• Main Authors: Murzin, Alexey G., Brenner, Steven E., Hubbard, Tim, Chothia, Cyrus
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 07-04-1995
• Subjects: Amino Acid Sequence; amino acid sequences; classification; Databases, Factual; evolutionary relationships; folds; molecular conformation; protein families; Protein Folding; protein structure; proteins; Proteins - chemistry; Proteins - classification; Sequence Analysis; superfamilies; protein families; superfamilies; folds; evolutionary relationships; scop; PDB
• ISSN: 0022-2836; 1089-8638
• DOI: 10.1016/S0022-2836(05)80134-2

To facilitate understanding of, and access to, the information available for protein structures, we have constructed the Structural Classification of Proteins (scop) database. This database provides a detailed and comprehensive description of the structural and evolutionary relationships of the proteins of known structure. It also provides for each entry links to co-ordinates, images of the structure, interactive viewers, sequence data and literature references. Two search facilities are available. The homology search permits users to enter a sequence and obtain a list of any structures to which it has significant levels of sequence similarity. The key word search finds, for a word entered by the user, matches from both the text of the scop database and the headers of Brookhaven Protein Databank structure files. The database is freely accessible on World Wide Web (WWW) with an entry point to URL
http://scop.mrc-lmb.cam.ac.uk/scop/
scop: an old English poet or minstrel (Oxford English Dictionary);
ckon: pile, accumulation (Russian Dictionary).