The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus

• Published in: Journal of Veterinary Medical Science Vol. 83; no. 6; pp. 990 - 993
• Main Authors: SUDO, Kasumi, YAMADA, Manabu, OCHIAI, Mariko, IWAMOTO, Shoko, SAKAKI, Hajime, KUSHIDA, Chiho, YAMASHITA, Maiko, YAMAMOTO, Atsushi, NAGASAKA, Takao, OIDEMIZU, Mikio, SAITO, Akito, YAMAMOTO, Kinya
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2021; The Japanese Society of Veterinary Science
• Subjects: button ulcer; classical swine fever virus; herniation of crypt; histopathology; Pathology; histopathology; classical swine fever virus; herniation of crypt; button ulcer
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.20-0654

We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs.