Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

Prior infection has primed most adult humans for a rapid neutralizing antibody (NAb) response when re-exposed to adenovirus. NAb induction can severely limit the efficacy of systemic re-administration of adenoviral gene therapy. We hypothesized that changing the fiber knob could overcome NAb. Immune...

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Bibliographic Details
Published in:	Gene therapy Vol. 15; no. 12; pp. 921 - 929
Main Authors:	Särkioja, M, Pesonen, S, Raki, M, Hakkarainen, T, Salo, J, Ahonen, M T, Kanerva, A, Hemminki, A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2008 Nature Publishing Group
Subjects:	Adenoviridae - genetics Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies Antibodies, Viral - immunology Antigens, Viral - genetics Antigens, Viral - immunology Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Capsid Proteins - genetics Carcinoma, Non-Small-Cell Lung - therapy Care and treatment Cell Biology Development and progression Explants Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Engineering Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Human Genetics Humans Immunology Industrial applications and implications. Economical aspects Infections Intravenous administration Lung - immunology Lung - virology Lung cancer Lung Neoplasms - immunology Lung Neoplasms - therapy Medical sciences Mice Mice, Inbred ICR Mice, Nude Nanotechnology original-article Patient outcomes Rodents Spleen Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumors Viral antibodies Viruses Xenograft Model Antitumor Assays Xenografts United States Finland seroswitching neutralizing antibody oncolytic adenovirus cancer Virus Adenoviridae Antibody Malignant tumor Gene therapy Vector Cancer
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