Asymmetric Hydrophosphonylation of Aldehydes using a Cinchona-Diaminomethylenemalononitrile Organocatalyst

For the asymmetric hydrophosphonylation of aldehydes, an efficient organocatalytic approach with a diaminomethylenemalononitrile‐based hydrogen‐bonding donor catalyst is presented. The catalyst induces high yields and excellent enantioselectivities (up to 98% yield, 96% ee).

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Bibliographic Details
Published in:	Advanced synthesis & catalysis Vol. 357; no. 18; pp. 3863 - 3867
Main Authors:	Hirashima, Shin-ichi, Arai, Ryoga, Nakashima, Kosuke, Kawai, Nobuaki, Kondo, Junko, Koseki, Yuji, Miura, Tsuyoshi
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 14-12-2015 WILEY‐VCH Verlag
Subjects:	Aldehydes asymmetric reactions Asymmetry Catalysis Catalysts diaminomethylenemalononitrile Hydrogen bonding hydrophosphonylation organocatalysts Pudovik reaction Synthesis
Online Access:	Get full text
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Summary:	For the asymmetric hydrophosphonylation of aldehydes, an efficient organocatalytic approach with a diaminomethylenemalononitrile‐based hydrogen‐bonding donor catalyst is presented. The catalyst induces high yields and excellent enantioselectivities (up to 98% yield, 96% ee).
Bibliography:	ArticleID:ADSC201500816 istex:AA2CBF64635058F1D4B3AB909A6196D0BF15224C ark:/67375/WNG-4WNJDFWR-H ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201500816