Mechanotransduction via TRPV4 regulates inflammation and differentiation in fetal mouse distal lung epithelial cells

Mechanical ventilation plays a central role in the injury of premature lungs. However, the mechanisms by which mechanical signals trigger an inflammatory cascade to promote lung injury are not well-characterized. Transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable mechanoreceptor c...

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Bibliographic Details
Published in:	Respiratory research Vol. 16; no. 1; p. 60
Main Authors:	Nayak, Pritha S, Wang, Yulian, Najrana, Tanbir, Priolo, Lauren M, Rios, Mayra, Shaw, Sunil K, Sanchez-Esteban, Juan
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 27-05-2015 BioMed Central
Subjects:	Animals Cell Differentiation - physiology Cells, Cultured Epithelial Cells - pathology Epithelial Cells - physiology Female Fetus Inflammation - metabolism Inflammation - pathology Mechanotransduction, Cellular - physiology Mice Mice, Inbred C57BL Pregnancy Respiratory Mucosa - embryology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology TRPV Cation Channels - biosynthesis
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