Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms

Cardiovascular disease is one of the leading causes of death worldwide, and evidence indicates a correlation between the inflammatory process and cardiac dysfunction. Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme are not recommended for long-term use because of potentially severe side effe...

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Bibliographic Details
Published in:	Brazilian journal of medical and biological research Vol. 47; no. 1; pp. 50 - 59
Main Authors:	Sakane, K K, Monteiro, C J, Silva, W, Silva, A R, Santos, P M, Lima, K F, Moraes, K C M
Format:	Journal Article
Language:	English
Published:	Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2014 Associação Brasileira de Divulgação Científica
Subjects:	Analysis Animals BIOLOGY Biomedical Sciences Blotting, Western Cardiovascular diseases Causes of Celecoxib Cell death Cell Line Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Cellular and molecular analyses COX-2 inhibitors Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase-2 inhibitor Dosage and administration Dose-Response Relationship, Drug Drug therapy Gene Expression Regulation - drug effects Gene Expression Regulation - genetics H9c2 cardiac cell line MEDICINE, RESEARCH & EXPERIMENTAL Myoblasts, Cardiac - drug effects Pyrazoles - pharmacology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - genetics Spectroscopy, Near-Infrared Sulfonamides - pharmacology Time Factors Cyclooxygenase-2 inhibitor H9c2 cardiac cell line Cell death Cellular and molecular analyses
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