Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients

To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT cuff from orotracheally intubated patients with MRSA respiratory infection. Prospective o...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 23; no. 1; p. 251
Main Authors:	Fernández-Barat, Laia, Motos, Ana, Panigada, Mauro, Álvarez-Lerma, Francisco, Viña, Lucía, Lopez-Aladid, Ruben, Ceccato, Adrian, Bassi, Gianluigi Li, Nicolau, David P, Lopez, Yuli, Muñoz, Laura, Guerrero, Laura, Soy, Dolors, Israel, Trinidad, Castro, Pedro, Torres, Antoni
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 10-07-2019 BioMed Central BMC
Subjects:	Aged Analysis of Variance Anti-Bacterial Agents - standards Anti-Bacterial Agents - therapeutic use Antibacterial agents APACHE Biofilm Biofilms - drug effects Biofilms - growth & development Chromatography Clinical trials Comparative analysis Critical care medicine Drug therapy Electron microscopy Endotracheal tube Female High performance liquid chromatography Hospital patients Hospitals Humans Intensive Care Units - organization & administration Intensive Care Units - statistics & numerical data Intubation, Intratracheal - adverse effects Intubation, Intratracheal - statistics & numerical data Linezolid Linezolid - standards Linezolid - therapeutic use Liquid chromatography Lung diseases Male Methicillin Methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Microscopy Microscopy, Electron, Scanning - methods Middle Aged Optical scanners Organ Dysfunction Scores Oxacillin Prospective Studies Respiratory infection Respiratory tract diseases Staphylococcal infections Staphylococcus aureus Staphylococcus aureus infections Vancomycin Vancomycin - standards Vancomycin - therapeutic use Spain Linezolid Biofilm Vancomycin Endotracheal tube Methicillin-resistant Staphylococcus aureus Respiratory infection
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