Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

• Published in: Molecular and Cellular Biology Vol. 21; no. 22; pp. 7707 - 7713
• Main Authors: Kim, Byong Su, Savinova, Olga V., Reedy, Mark V., Martin, Janice, Lun, Yi, Gan, Lin, Smith, Richard S., Tomarev, Stanislav I., John, Simon W. M., Johnson, Randy L.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01-11-2001; Taylor & Francis
• Subjects: Animals; Cytoskeletal Proteins; Eye - metabolism; Eye - pathology; Eye Proteins - genetics; Eye Proteins - physiology; Gene Expression; Gene Targeting - methods; Glaucoma, Open-Angle - pathology; GLC1A gene; Glycoproteins - genetics; Glycoproteins - physiology; Humans; Intraocular Pressure; Mammalian Genetic Models with Minimal or Complex Phenotypes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Myoc gene; Myocilin; RNA, Messenger; TIGR gene
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.21.22.7707-7713.2001

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