An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation

The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Au...

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Published in:	Internal Medicine Vol. 62; no. 23; pp. 3519 - 3523
Main Authors:	Tsuzuku, Akifumi, Asano, Fumihiro, Katayama, Masaki, Mori, Kosuke, Sasaki, Yui, Kuzunishi, Yutaro, Taguchi, Mayuka, Muto, Yuya, Baba, Yasutomo, Tsuchida, Akimasa, Kato, Tomoya, Murakami, Anri, Masuda, Atsunori, Yoshizane, Takashi, Suzuki, Jun
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Society of Internal Medicine 01-12-2023 Japan Science and Technology Agency
Subjects:	Autopsy autopsy pathology Case Report Coronaviruses COVID-19 COVID-19 - complications diffuse alveolar damage Fibrosis Humans Inflammation Internal medicine interstitial lung disease Lung diseases Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - pathology post-COVID-19 post-COVID-19 diffuse alveolar damage interstitial lung disease autopsy pathology
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Abstract	The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
AbstractList	The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
ArticleNumber	2006-23
Author	Murakami, Anri Asano, Fumihiro Tsuchida, Akimasa Kato, Tomoya Tsuzuku, Akifumi Kuzunishi, Yutaro Muto, Yuya Baba, Yasutomo Yoshizane, Takashi Mori, Kosuke Katayama, Masaki Sasaki, Yui Suzuki, Jun Masuda, Atsunori Taguchi, Mayuka
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Cites_doi	10.1007/s00134-022-06877-w 10.1183/23120541.00004-2022 10.5858/arpa.2021-0519-SA 10.2491/jjsth.32.708 10.5858/arpa.2020-0786-SA 10.1038/s41591-021-01283-z 10.1126/sciadv.abo6783 10.1148/radiol.2021210972 10.1038/s41379-020-0603-3 10.1080/07853890.2022.2039954
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SubjectTerms	Autopsy autopsy pathology Case Report Coronaviruses COVID-19 COVID-19 - complications diffuse alveolar damage Fibrosis Humans Inflammation Internal medicine interstitial lung disease Lung diseases Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - pathology post-COVID-19
Title	An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation
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