Neutrophils in COVID-19

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has u...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 652470
Main Authors:	Reusch, Nico, De Domenico, Elena, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Baßler, Kevin, Schultze, Joachim L, Aschenbrenner, Anna C
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 25-03-2021
Subjects:	COVID-19 COVID-19 - epidemiology COVID-19 - immunology granulocytes Humans Immunology neutrophils Neutrophils - immunology Pandemics SARS-CoV-2 SARS-CoV-2 - immunology scRNA-seq viral infection COVID-19 granulocytes SARS-CoV-2 scRNA-seq viral infection clinical trials neutrophils
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Summary:	Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional and functional diversity as well as their developmental trajectories. These new findings are important to better understand the many facets of neutrophil involvement not only in COVID-19 but also many other acute or chronic inflammatory diseases, both communicable and non-communicable. Here, we highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophils and their reactivity in patients with COVID-19.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Reviewed by: Moritz Leppkes, University Hospital Erlangen, Germany; Mieke Gouwy, KU Leuven, Belgium Edited by: Markus H. Hoffmann, University of Erlangen Nuremberg, Germany
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2021.652470