Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis

Axon pruning is a common phenomenon in neural circuit development. Previous studies demonstrate that the engulfing action of glial cells is essential in this process. The underlying molecular mechanisms, however, remain unknown. We show that draper ( drpr) and ced-6, which are essential for the clea...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 50; no. 6; pp. 855 - 867
Main Authors:	Awasaki, Takeshi, Tatsumi, Ryoko, Takahashi, Kuniaki, Arai, Kunizo, Nakanishi, Yoshinobu, Ueda, Ryu, Ito, Kei
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15-06-2006 Elsevier Limited
Subjects:	Animals Animals, Genetically Modified Apoptosis - physiology Axons - physiology Caenorhabditis elegans Proteins - physiology Cloning DEVBIO Drosophila Drosophila Proteins - physiology Gene Expression Regulation, Developmental - physiology Genes Hybridization Insects Membrane Proteins - physiology Metamorphosis, Biological - physiology MOLNEURO Nerve Net Neurons Phosphoproteins - physiology Proteins Rats Rodents Software Studies SYSNEURO SYSNEURO DEVBIO MOLNEURO
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