Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring
ABSTRACT With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure m...
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| Published in: | Developmental psychobiology Vol. 58; no. 4; pp. 427 - 438 |
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| Main Authors: | , , , , , , , , |
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| Abstract | ABSTRACT
With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect‐related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non‐stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety‐like behavior by increasing anxiety in non‐stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long‐term programming effects of early‐life exposure to SSRIs on brain and behavior. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58: 427–438, 2016. |
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| AbstractList | With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety-like behavior by increasing anxiety in non-stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long-term programming effects of early-life exposure to SSRIs on brain and behavior. With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety-like behavior by increasing anxiety in non-stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long-term programming effects of early-life exposure to SSRIs on brain and behavior. Dev Psychobiol 58: 427-438, 2016. ABSTRACT With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect‐related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non‐stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety‐like behavior by increasing anxiety in non‐stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long‐term programming effects of early‐life exposure to SSRIs on brain and behavior. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58: 427–438, 2016. |
| Author | Van den Hove, Daniel L. A. Machiels, Barbie Kumar, Neha Kenis, Gunter Pawluski, Jodi L. Boulle, Fabien Steinbusch, Harry W. M. Kroeze, Yvet Homberg, Judith R. |
| Author_xml | – sequence: 1 givenname: Fabien surname: Boulle fullname: Boulle, Fabien email: : Jodi L. Pawluski, University of Rennes 1, Campus Beaulieu Bat 13, Room 135/2, 35042 Rennes Cedex, France, j.pawluski@gmail.com organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, Maastricht, The Netherlands – sequence: 2 givenname: Jodi L. surname: Pawluski fullname: Pawluski, Jodi L. email: : Jodi L. Pawluski, University of Rennes 1, Campus Beaulieu Bat 13, Room 135/2, 35042 Rennes Cedex, France, j.pawluski@gmail.com organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, Maastricht, The Netherlands – sequence: 3 givenname: Judith R. surname: Homberg fullname: Homberg, Judith R. organization: Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Radboud University Medical Centre, Department of Cognitive Neuroscience, Geert Grooteplein 21, The Netherlands, 6525 EZ Nijmegen – sequence: 4 givenname: Barbie surname: Machiels fullname: Machiels, Barbie organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, The Netherlands, Maastricht – sequence: 5 givenname: Yvet surname: Kroeze fullname: Kroeze, Yvet organization: Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Radboud University Medical Centre, Department of Cognitive Neuroscience, Geert Grooteplein 21, The Netherlands, 6525 EZ Nijmegen – sequence: 6 givenname: Neha surname: Kumar fullname: Kumar, Neha organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, The Netherlands, Maastricht – sequence: 7 givenname: Harry W. M. surname: Steinbusch fullname: Steinbusch, Harry W. M. organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, The Netherlands, Maastricht – sequence: 8 givenname: Gunter surname: Kenis fullname: Kenis, Gunter organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, The Netherlands, Maastricht – sequence: 9 givenname: Daniel L. A. surname: Van den Hove fullname: Van den Hove, Daniel L. A. organization: School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200 MD, Maastricht, The Netherlands |
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(e_1_2_6_9_1) 1998; 18 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_56_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_58_1 e_1_2_6_63_1 e_1_2_6_42_1 e_1_2_6_65_1 e_1_2_6_21_1 e_1_2_6_40_1 e_1_2_6_61_1 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_67_1 e_1_2_6_27_1 e_1_2_6_46_1 e_1_2_6_69_1 |
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With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period,... With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have... |
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| SubjectTerms | Animals Anxiety - chemically induced Anxiety - etiology BDNF Behavior, Animal - drug effects Behavior, Animal - physiology Brain-Derived Neurotrophic Factor - metabolism depression Development Biology Disease Models, Animal Embryology and Organogenesis Female Fluoxetine - administration & dosage Fluoxetine - adverse effects Gene Expression hippocampus Hippocampus - drug effects Hippocampus - metabolism Life Sciences Male Neurobiology Neurons and Cognition neuroplasticity Pregnancy Prenatal Exposure Delayed Effects prenatal stress Psychology and behavior Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - adverse effects sex differences SSRI Stress, Psychological - complications TrkB |
| Title | Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring |
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