Reduction of the active-site iron by potent inhibitors of lipoxygenases

Lipoxygenases are non-heme iron dioxygenases that catalyze the oxygenation of polyunsaturated fatty acids. Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of t...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 266; no. 13; pp. 8225 - 8229
Main Authors:	Nelson, M.J, Batt, D.G, Thompson, J.S, Wright, S.W
Format:	Journal Article
Language:	English
Published:	Bethesda, MD American Society for Biochemistry and Molecular Biology 05-05-1991
Subjects:	Analytical, structural and metabolic biochemistry Binding Sites Biological and medical sciences Electron Spin Resonance Spectroscopy enzyme activity enzyme inhibitors Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Glycine max Glycine max - enzymology Hydroxamic Acids - pharmacology iron Iron - metabolism lipoxygenase Lipoxygenase Inhibitors Naphthols - pharmacology Oxidation-Reduction Oxidoreductases Active site EPR spectrometry Enzyme inhibitor Iron Inflammation Models NMR spectrometry Soybean Lipoxygenase Mechanism of action Fatty acids
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