Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment

• Published in: Clinical & developmental immunology Vol. 2010; no. 2010; pp. 1 - 17
• Main Authors: Hamšíková, Eva, Vonka, Vladimír, Humlová, Zuzana, Roth, Zdeněk, Šterzl, Ivan, Králíková, Petra, Klamová, Hana, Janatková, Ivana, Malíčková, Karin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2010; Hindawi Publishing Corporation; Hindawi Limited
• Subjects: Adult; Antineoplastic Agents - therapeutic use; Benzamides; C-Reactive Protein - analysis; Complement System Proteins - analysis; Dasatinib; E coli; Female; Humans; Hydroxyurea - therapeutic use; Imatinib Mesylate; Immune system; Immunity, Innate; Immunoglobulins - blood; Immunologic Factors - therapeutic use; Immunology; Interferon-alpha - therapeutic use; Interleukin-6 - blood; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy; Longitudinal Studies; Lupus; Male; Mathematical models; Middle Aged; Piperazines - therapeutic use; Protein Kinase Inhibitors - therapeutic use; Pyrimidines - therapeutic use; T-Lymphocytes - metabolism; Teaching hospitals; Thiazoles - therapeutic use; Treatment Outcome; Czech Republic
• ISSN: 1740-2522; 2314-8861; 1740-2530; 2314-7156
• DOI: 10.1155/2010/137320

In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment.