A Bayesian non-inferiority approach using experts' margin elicitation - application to the monitoring of safety events

When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have been developed, but commonly utilize historical placebo-controlled data to define the margin,...

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Bibliographic Details
Published in:	BMC medical research methodology Vol. 19; no. 1; p. 187
Main Authors:	Aupiais, Camille, Alberti, Corinne, Schmitz, Thomas, Baud, Olivier, Ursino, Moreno, Zohar, Sarah
Format:	Journal Article
Language:	English
Published:	England BioMed Central 18-09-2019 BMC
Subjects:	Bayesian analysis Bayesian inference Children Clinical decision making Clinical trial Clinical trials Decision making Elicitation Life Sciences Medical research Mixture model Newborn babies Non-inferiority Pregnancy Research methodology Respiratory distress syndrome Santé publique et épidémiologie France Mixture model Clinical trial Elicitation Children Bayesian inference Non-inferiority
Online Access:	Get full text
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