Transforming Properties of YAP, a Candidate Oncogene on the Chromosome 11q22 Amplicon

In a screen for gene copy-number changes in mouse mammary tumors, we identified a tumor with a small 350-kb amplicon from a region that is syntenic to a much larger locus amplified in human cancers at chromosome 11q22. The mouse amplicon contains only one known gene, Yap, encoding the mammalian orth...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 33; pp. 12405 - 12410
Main Authors:	Overholtzer, Michael, Zhang, Jianmin, Smolen, Gromoslaw A., Muir, Beth, Li, Wenmei, Sgroi, Dennis C., Deng, Chu-Xia, Brugge, Joan S., Haber, Daniel A.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 15-08-2006 National Acad Sciences
Subjects:	3T3 cells Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - physiology Biological Sciences Cancer Cell Cycle Proteins Cell growth Cell Line, Tumor Cell lines Cell Proliferation Cell Shape Cell Transformation, Neoplastic Cells Chromosomes Chromosomes, Human, Pair 11 Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Gene loci Genes Humans Insects Mammary Glands, Human - cytology Mice Neoplasms - genetics Neoplasms - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogenes Phosphoproteins - genetics Phosphoproteins - metabolism Rodents Signal Transduction - physiology Trans-Activators - genetics Trans-Activators - metabolism Tumors
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