Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoco...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 24; no. 15; p. 2731
Main Authors:	Edueng, Khadijah, Mahlin, Denny, Gråsjö, Johan, Nylander, Olivia, Thakrani, Manish, Bergström, Christel A S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-07-2019 MDPI
Subjects:	Aging Amorphization amorphous Calorimetry Calorimetry, Differential Scanning Chemical Phenomena crystal growth Crystal lattices Crystal structure Crystallinity Crystallization crystallization kinetics Differential scanning calorimetry dissolution Drug dosages Drug Stability Energy Farmaceutisk vetenskap Glibenclamide Humidity Hydrochlorothiazide Hydrocortisone Indapamide Ingredients Ketoconazole Kinetics nucleation pathway Oral administration Pharmaceutical Preparations - chemistry Pharmaceutical Science Pharmaceuticals physical aging Preservation, Biological Raman spectroscopy Relative humidity Solid state Solubility solvent shift Spectrum Analysis, Raman spray-drying Sulfathiazole Supersaturation supersaturation potential Time Factors X ray powder diffraction X-ray diffraction physical aging amorphous supersaturation potential crystallization kinetics dissolution crystallization crystal growth solvent shift nucleation pathway spray-drying
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