Genome Regulation by Polycomb and Trithorax Proteins

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggest...

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Bibliographic Details
Published in:	Cell Vol. 128; no. 4; pp. 735 - 745
Main Authors:	Schuettengruber, Bernd, Chourrout, Daniel, Vervoort, Michel, Leblanc, Benjamin, Cavalli, Giacomo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 23-02-2007 Elsevier
Subjects:	Animals Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Epigenesis, Genetic - genetics Evolution, Molecular Gene Expression Regulation, Developmental - genetics Genetics Histones - genetics Histones - metabolism Humans Life Sciences Polycomb-Group Proteins Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference - physiology RNA, Untranslated - genetics RNA, Untranslated - metabolism
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Summary:	Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2007.02.009