From SARS-CoV to SARS-CoV-2: safety and broad-spectrum are important for coronavirus vaccine development

• Published in: Microbes and infection Vol. 22; no. 6-7; pp. 245 - 253
• Main Authors: Ma, Cuiqing, Su, Shan, Wang, Jiachao, Wei, Lin, Du, Lanying, Jiang, Shibo
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-07-2020; Institut Pasteur. Published by Elsevier Masson SAS
• Subjects: 2019-nCoV; Animals; Betacoronavirus - genetics; Coronavirus Infections - classification; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; COVID-19; COVID-19 Vaccines; Cross Protection; HCoV-19; Humans; Pandemics - prevention & control; Pneumonia, Viral - immunology; Pneumonia, Viral - prevention & control; SARS-CoV; SARS-CoV-2; Severe Acute Respiratory Syndrome - immunology; Severe Acute Respiratory Syndrome - prevention & control; Vaccine; Vaccines, Inactivated - immunology; Viral Vaccines - classification; Viral Vaccines - immunology; SARS-CoV-2; HCoV-19; Vaccine; Cross-protection; 2019-nCoV; SARS-CoV
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/j.micinf.2020.05.004

The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.